Journal article
Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1 alpha in adulthood
American Journal of Physiology: Endocrinology and Metabolism, Vol.302(10), pp.E1221-E1230
2012
PMID: 22354784
Abstract
Laker RC, Wlodek ME, Wadley GD, Gallo LA, Meikle PJ, McConell GK. Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1 alpha in adulthood. Am J Physiol Endocrinol Metab 302: E1221-E1230, 2012. First published February 21, 2012; doi:10.1152/ajpendo.00583.2011.-We have previously shown that 4 wk of exercise training early in life normalizes the otherwise greatly reduced pancreatic beta-cell mass in adult male rats born small. The aim of the current study was to determine whether a similar normalization in adulthood of reduced skeletal muscle mitochondrial biogenesis markers and alterations in skeletal muscle lipids of growth-restricted male rats occurs following early exercise training. Bilateral uterine vessel ligation performed on day 18 of gestation resulted in Restricted offspring born small (P < 0.05) compared with both sham-operated Controls and a sham-operated Reduced litter group. Offspring remained sedentary or underwent treadmill running from 5-9 (early exercise) or 20-24 (later exercise) wk of age. At 24 wk of age, Restricted and Reduced litter offspring had lower (P < 0.05) skeletal muscle peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) protein expression compared with Control offspring. Early exercise training had the expected effect of increasing skeletal muscle markers of mitochondrial biogenesis, but, at this early age (9 wk), there was no deficit in Restricted and Reduced litter skeletal muscle mitochondrial biogenesis. Unlike our previous observations in pancreatic beta-cell mass, there was no "reprogramming" effect of early exercise on adult skeletal muscle such that PGC-1 alpha was lower in adult Restricted and Reduced litter offspring irrespective of exercise training. Later exercise training increased mitochondrial biogenesis in all groups. In conclusion, although the response to exercise training remains intact, early exercise training in rats born small does not have a reprogramming effect to prevent deficits in skeletal muscle markers of mitochondrial biogenesis in adulthood.
Details
- Title
- Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1 alpha in adulthood
- Authors
- Rhianna C. Laker (Author) - University of MelbourneMary E. Wlodek (Author) - University of MelbourneGlenn D. Wadley (Author) - Deakin UniversityLinda A. Gallo (Author) - University of MelbournePeter J. Meikle (Author) - Baker Heart and Diabetes InstituteGlenn K. McConell (Corresponding Author) - Victoria Univ, Inst Sport Exercise & Act Living, Melbourne, Vic 8001, Australia
- Publication details
- American Journal of Physiology: Endocrinology and Metabolism, Vol.302(10), pp.E1221-E1230
- Publisher
- American Physiological Society
- DOI
- 10.1152/ajpendo.00583.2011
- ISSN
- 1522-1555
- PMID
- 22354784
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99679193302621
- Output Type
- Journal article
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- Endocrinology & Metabolism
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