Executive function in adolescents with PKU and their siblings: Associations with biochemistry

Rachael Sharman; K Sullivan; Ross Young; J McGill

doi:10.1016/j.ymgmr.2015.08.001

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Executive function in adolescents with PKU and their siblings: Associations with biochemistry

Journal article

Open access

Peer reviewed

Executive function in adolescents with PKU and their siblings: Associations with biochemistry

Rachael Sharman, K Sullivan, Ross Young and J McGill

Molecular Genetics and Metabolism, Vol.4, pp.87-88

2015

DOI: https://doi.org/10.1016/j.ymgmr.2015.08.001

PMCID: PMC4750585

PMID: 26937416

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Abstract

phenylketonuria

adolescents

phenylalanine:tyrosine ratio

executive function

dopamine

Previous research shows consistent and marked executive function impairment in children with early and continuously treated phenylketonuria. This between groups analysis (phenylketonuria group vs sibling controls) found no significant differences in executive function (although adolescents with phenylketonuria performed slightly worse than their siblings). Biochemical relationships with executive function were confined to longterm measures of high phenylalanine:tyrosine ratio exposure, as well as tyrosine exposure independent of phenylalanine. This study suggests that early and continuously treated PKU results in non-significant EF differences (compared to siblings), although the influence of long-term exposure to poorer metabolic control is still evident.

Details

Title: Executive function in adolescents with PKU and their siblings: Associations with biochemistry
Authors: Rachael Sharman (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
K Sullivan (Author) - Queensland University of Technology
Ross Young (Author) - Queensland University of Technology
J McGill (Author) - Lady Cilento Children's Hospital
Publication details: Molecular Genetics and Metabolism, Vol.4, pp.87-88
Publisher: Academic Press
Date published: 2015
DOI: 10.1016/j.ymgmr.2015.08.001
ISSN: 1096-7192
PMID: 26937416; PMC4750585
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation); School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449325602621
Output Type: Journal article

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