Executive Functioning of 4 Children With Hyperphenylalaninemia From Childhood to Adolescence

Rachael Sharman; Karen A Sullivan; Toni Jones; Ross Young; Jim McGill

doi:10.1542/peds.2013-4200

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Executive Functioning of 4 Children With Hyperphenylalaninemia From Childhood to Adolescence

Journal article

Peer reviewed

Executive Functioning of 4 Children With Hyperphenylalaninemia From Childhood to Adolescence

Rachael Sharman, Karen A Sullivan, Toni Jones, Ross Young and Jim McGill

Pediatrics, Vol.135(4), pp.e1072-e1074

2015

DOI: https://doi.org/10.1542/peds.2013-4200

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Abstract

cognitive

executive function

hyperphenylalaninemia

neuropsychology

phenylalanine

Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalaninemia. Two sibling pairs with mild hyperphenylalaninemia underwent neuropsychological examination in early childhood and again in adolescence using EF tests that were highly sensitive to phenylalanine exposure. By early adolescence, none of the 4 children demonstrated EF impairment. The children demonstrated a typical developmental trajectory of EF from childhood to adolescence, given phenylalanine exposure consistent with their condition.

Details

Title: Executive Functioning of 4 Children With Hyperphenylalaninemia From Childhood to Adolescence
Authors: Rachael Sharman (Author) - University of the Sunshine Coast - Faculty of Arts and Business
Karen A Sullivan (Author) - Queensland University of Technology
Toni Jones (Author) - Great Southern Psychiatric and Psychological Services
Ross Young (Author) - Queensland University of Technology
Jim McGill (Author) - Lady Cilento Children's Hospital
Publication details: Pediatrics, Vol.135(4), pp.e1072-e1074
Publisher: American Academy of Pediatrics
Date published: 2015
DOI: 10.1542/peds.2013-4200
ISSN: 0031-4005
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation); School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449811002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Pediatrics

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