Excitatory and inhibitory neurometabolites in anorexia nervosa: A systematic review of proton magnetic resonance spectroscopy studies

Jules S Mitchell; Toomas E Anijärv; Jacob L Levenstein; Daniel Hermens; Jim Lagopoulos

doi:10.1016/j.neubiorev.2023.105279

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Excitatory and inhibitory neurometabolites in anorexia nervosa: A systematic review of proton magnetic resonance spectroscopy studies

Journal article

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Excitatory and inhibitory neurometabolites in anorexia nervosa: A systematic review of proton magnetic resonance spectroscopy studies

Jules S Mitchell, Toomas E Anijärv, Jacob L Levenstein, Daniel Hermens and Jim Lagopoulos

Neuroscience & Biobehavioral Reviews, Vol.152, pp.1-12

2023

DOI: https://doi.org/10.1016/j.neubiorev.2023.105279

PMID: 37307945

Appears in Thompson Institute Research Collection

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Abstract

Proton magnetic resonance spectroscopy

anorexia nervosa

neurometabolites

Systematic review

Eating disorders

Neuroimaging

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

The dysregulation of excitatory and inhibitory neurotransmission is considered a pathological marker of Anorexia Nervosa (AN), however, no systematic evaluation of the proton Magnetic Resonance Spectroscopy (1H-MRS) literature has been conducted to date. Accordingly, we conducted a systematic review of neurometabolite differences between individuals with AN and healthy controls (HC). A comprehensive database search (until June 2023) identified seven studies meeting inclusion criteria. Samples included adolescents and adults with similar mean age (AN: 22.20 HC: 22.60), and female percentages (AN: 98%; HC: 94%). The review found a considerable need for improving study design and the reporting of MRS sequence parameters and analysis. Reduced glutamate concentrations in the ACC and OCC, and reduced Glx concentrations in the ACC were reported by one and two studies, respectively. Lastly, only one study to date has quantified GABA concentrations, with no significant differences found. In conclusion, there is currently insufficient evidence of excitatory and inhibitory neurometabolites changes in AN. As the 1H-MRS literature in AN increases, the key questions herein proposed must be revisited.

Details

Title: Excitatory and inhibitory neurometabolites in anorexia nervosa: A systematic review of proton magnetic resonance spectroscopy studies
Authors: Jules S Mitchell (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Toomas E Anijärv (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jacob L Levenstein (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Daniel Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Publication details: Neuroscience & Biobehavioral Reviews, Vol.152, pp.1-12
Publisher: Elsevier Ltd
Date published: 2023
DOI: 10.1016/j.neubiorev.2023.105279
ISSN: 1873-7528
PMID: 37307945
Grant note: Australian Government Research Training Partnership (RTP)
Organisation Unit: School of Health - Biomedicine; Thompson Institute
Language: English
Record Identifier: 99737598402621
Output Type: Journal article

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