Journal article
Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution
Genome Research, Vol.22(3), pp.498-507
2012
Abstract
We report here the isolation and sequencing of 10 Y-specific tammar wallaby (Macropus eugenii ) BAC clones, revealing five hitherto undescribed tammarwallaby Y genes (in addition to the five genes already described) and several pseudogenes. Some genes on the wallaby Y display testis-specific expression, but most have low widespread expression. All have partners on the tammar X, along with homologs on the human X. Nonsynonymous and synonymous substitution ratios for nine of the tammar XY gene pairs indicate that they are each under purifying selection. All 10 were also identified as being on the Y in Tasmanian devil (Sarcophilus harrisii; a distantly related Australian marsupial); however, seven have been lost from the human Y. Maximum likelihood phylogenetic analyses of the wallaby YX genes, with respective homologs from other vertebrate representatives, revealed that three marsupial Y genes (HCFC1X/Y, MECP2X/Y, and HUWE1X/Y) were members of the ancestral therian pseudoautosomal region (PAR) at the time of the marsupial/eutherian split; three XY pairs (SOX3/SRY, RBMX/Y, and ATRX/Y) were isolated fromeach other before the marsupial/eutherian split, and the remaining three (RPL10X/Y, PHF6X/Y, and UBA1/UBE1Y) have a more complex evolutionary history. Thus, the small marsupial Y chromosome is surprisingly rich in ancient genes that are retained in at least Australian marsupials and evolved from testis - brain expressed genes on the X. © 2012 by Cold Spring Harbor Laboratory Press.
Details
- Title
- Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution
- Authors
- V J Murtagh (Author) - Australian National UniversityDenis O'Meally (Author) - Australian National UniversityN Sankovic (Author) - Australian National UniversityM L Delbridge (Author) - Australian National UniversityY Kuroki (Author) - RIKEN Research Center of Allergy and Immunology, JapanJ L Boore (Author) - Genome Project Solutions, United StatesA Toyoda (Author) - National Institute of Genetics, United StatesK S Jordan (Author) - Australian National UniversityA J Pask (Author) - University of MelbourneM B Renfree (Author) - University of MelbourneA Fujiyama (Author) - National Institute of Informatics, JapanJ A Marshall Graves (Author) - Australian National UniversityP D Waters (Author) - Australian National University
- Publication details
- Genome Research, Vol.22(3), pp.498-507
- Publisher
- Cold Spring Harbor Laboratory Press
- Date published
- 2012
- DOI
- 10.1101/gr.120790.111
- ISSN
- 1088-9051
- Copyright note
- Copyright © 2012 The Authors. This article is distributed under a Creative Commons CC-BY-NC Licence (Attribution-NonCommercial 4.0 International Licence, http://creativecommons.org/licences/by-nc/4.0/)
- Organisation Unit
- University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451014702621
- Output Type
- Journal article
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