Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle

P Patel; L de Boer; Peter Timms; Wilhelmina M Huston

doi:10.1016/j.micinf.2014.07.003

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Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle

Journal article

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Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle

P Patel, L de Boer, Peter Timms and Wilhelmina M Huston

Microbes and Infection, Vol.16(8), pp.690-694

2014

DOI: https://doi.org/10.1016/j.micinf.2014.07.003

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Abstract

chlamydia

HtrA

protease

inhibitor

Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after HtrA was inhibited during the replicative phase. Mid-replicative phase addition of JO146 was also significantly detrimental to Chlamydia pecorum, Chlamydia suis and Chlamydia cavie. These data combined indicate that HtrA has a conserved critical role during the replicative phase of the chlamydial developmental cycle.

Details

Title: Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle
Authors: P Patel (Author) - Queensland University of Technology
L de Boer (Author) - Queensland University of Technology
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Wilhelmina M Huston (Author) - Queensland University of Technology
Publication details: Microbes and Infection, Vol.16(8), pp.690-694
Publisher: Elsevier Masson
Date published: 2014
DOI: 10.1016/j.micinf.2014.07.003
ISSN: 1286-4579
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99448875802621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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