Event-related wave activity in the EEG provides new marker of ADHD

D M Alexander; Daniel F Hermens; H A D Keage; C R Clark; L M Williams; M R Kohn; S D Clarke; C Lamb; E Gordon

doi:10.1016/j.clinph.2007.09.119

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Event-related wave activity in the EEG provides new marker of ADHD

Journal article

Peer reviewed

Event-related wave activity in the EEG provides new marker of ADHD

D M Alexander, Daniel F Hermens, H A D Keage, C R Clark, L M Williams, M R Kohn, S D Clarke, C Lamb and E Gordon

Clinical Neurophysiology, Vol.119(1), pp.163-179

2008

DOI: https://doi.org/10.1016/j.clinph.2007.09.119

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Abstract

EEG

ADHD

phase dynamics

hyperactivity/impulsivity

stimulant medication

Objective: This study examines the utility of new measures of event-related spatio-temporal waves in the EEG as a marker of ADHD, previously shown to be closely related to the P3 ERP in an adult sample. Methods: Wave activity in the EEG was assessed during both an auditory Oddball and a visual continuous performance task (CPT) for an ADHD group ranging in age from 6 to 18 years and comprising mostly Combined and Inattentive subtypes, and for an age and gender matched control group. Results: The ADHD subjects had less wave activity at low frequencies (∼1 Hz) during both tasks. For auditory Oddball targets, this effect was shown to be related to smaller P3 ERP amplitudes. During CPT, the ∼1 Hz wave activity in the ADHD subjects was inversely related to clinical and behavioral measures of hyperactivity and impulsivity. CPT wave activity at ∼1 Hz was seen to "normalise" following treatment with stimulant medication. Conclusions: The results identify a deficit in low frequency wave activity as a new marker for ADHD associated with levels of hyperactivity and impulsivity. Significance: The marker is evident across a range of tasks and may be specific to ADHD. While lower ∼1 Hz activity partly accounts for reduced P3 ERPs in ADHD, the effect also arises for tasks that do not elicit a P3. Deficits in behavioral inhibition are hypothesized to arise from underlying dysregulation of cortical inhibition. Crown Copyright © 2007.

Details

Title: Event-related wave activity in the EEG provides new marker of ADHD
Authors: D M Alexander (Author) - Brain Resource Company
Daniel F Hermens (Author) - Westmead Millennium Institute
H A D Keage (Author) - Flinders University
C R Clark (Author) - Flinders University
L M Williams (Author) - Westmead Millennium Institute
M R Kohn (Author) - Westmead Millennium Institute
S D Clarke (Author) - Westmead Millennium Institute
C Lamb (Author) - Adelaide Women's and Children's Hospital
E Gordon (Author) - Westmead Hospital
Publication details: Clinical Neurophysiology, Vol.119(1), pp.163-179
Publisher: Elsevier Ireland Ltd.
Date published: 2008
DOI: 10.1016/j.clinph.2007.09.119
ISSN: 1388-2457
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451145502621
Output Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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