Evaluation of a PGP3 ELISA for surveillance of the burden of Chlamydia infection in women from Australia and Samoa

Rami Mazraani; Peter Timms; Philip C Hill; Tamaailau Suaalii-Sauni; Tavita Niupulusu; Seiuli V A Temese; Liai Iosefa-Siitia; Leveti Auvaa; Siuomatautu A Tapelu; Maauga F Motu; Antoinette Righarts; Michael S Walsh; Luk Rombauts; John A Allan; Patrick Horner; Wilhelmina M Huston

doi:10.1093/femspd/ftz031

Back

Evaluation of a PGP3 ELISA for surveillance of the burden of Chlamydia infection in women from Australia and Samoa

Journal article

Open access

Peer reviewed

Evaluation of a PGP3 ELISA for surveillance of the burden of Chlamydia infection in women from Australia and Samoa

Rami Mazraani, Peter Timms, Philip C Hill, Tamaailau Suaalii-Sauni, Tavita Niupulusu, Seiuli V A Temese, Liai Iosefa-Siitia, Leveti Auvaa, Siuomatautu A Tapelu, Maauga F Motu, …

Pathogens and Disease, Vol.77(3), ftz031

2019

DOI: https://doi.org/10.1093/femspd/ftz031

Files and links (2)

pdf

PDF - Published Version (Open Access)154.88 kBDownload View

Published Version PDF - Published Version (Open Access) Open Access CC BY-NC V4.0

url

https://doi.org/10.1093/femspd/ftz031View

Published Version

Abstract

serology

sub-fertility

chlamydia

tubal factor infertility

ELISA

sero-epidemiology

Serological assays can be used to investigate the population burden of infection and potentially sequelae from Chlamydia. We investigated the PGP3 ELISA as a seroepidemiological tool for infection or sub-fertility in Australian and Samoan women. The PGP3 ELISA absorbance levels were compared between groups of women with infertility, dertile, and current chlamydial infections. In the Australian groups, women with chlamydial tubal factor infertility had significantly higher absorbance levels in the PGP3 ELISA compared to fertile women (p<0.0001), but not when compared to women with current chlamydial infection (p=0.44). In the Samoan study, where the prevalence of chlamydial infections is much higher there were significant differences in the PGP3 ELISA absorbance levels between chlamydial sub-fertile women and fertile women (p=0.003). There was no difference between chlamydial sub-fertile women and women with a current infection (p=0.829). The results support that the PGP3 assay is effective for sero-epidemiological analysis of burden of infection, but not for evaluation of chlamydial pathological sequelae such as infertility

Details

Title: Evaluation of a PGP3 ELISA for surveillance of the burden of Chlamydia infection in women from Australia and Samoa
Authors: Rami Mazraani (Author)
Peter Timms (Author) - University of the Sunshine Coast, Queensland, Faculty of Science, Health, Education and Engineering
Philip C Hill (Author)
Tamaailau Suaalii-Sauni (Author)
Tavita Niupulusu (Author)
Seiuli V A Temese (Author)
Liai Iosefa-Siitia (Author)
Leveti Auvaa (Author)
Siuomatautu A Tapelu (Author)
Maauga F Motu (Author)
Antoinette Righarts (Author)
Michael S Walsh (Author)
Luk Rombauts (Author)
John A Allan (Author)
Patrick Horner (Author)
Wilhelmina M Huston (Corresponding Author)
Publication details: Pathogens and Disease, Vol.77(3), ftz031
Publisher: Oxford University Press
Date published: 2019
DOI: 10.1093/femspd/ftz031
ISSN: 2049-632X
Copyright note: Copyright © FEMS 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Organisation Unit: Faculty of Science, Health, Education and Engineering; University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99451112402621
Output Type: Journal article

Metrics

10 File views/ downloads

462 Record Views

4 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites