Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

H. J Hugo; N. P. A. D Gunasinghe; B. G Hollier; T Tanaka; T Blick; A Toh; P Hill; C Gilles; M Waltham; E. W Thompson

doi:10.1186/s13058-017-0880-z

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Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

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Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

H. J Hugo, N. P. A. D Gunasinghe, B. G Hollier, T Tanaka, T Blick, A Toh, P Hill, C Gilles, M Waltham and E. W Thompson

Breast Cancer Research, Vol.19(1), pp.1-25

2017

DOI: https://doi.org/10.1186/s13058-017-0880-z

PMCID: PMC5530912

PMID: 28750639

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Abstract

Epithelial-mesenchymal plasticity

Breast cancer

Proliferation

Metastasis

E-cadherin

Epithelial-to-mesenchymal transition

Background: Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased proliferation. Proliferation may be restored in secondary metastases by mesenchymal-to-epithelial transition (MET). We tested whether E-cadherin maintains epithelial proliferation in MDA-MB-468 breast cancer cells, facilitating metastatic colonization in severe combined immunodeficiency (SCID) mice.

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Title: Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin
Authors: H. J Hugo (Author) - Queensland University of Technology
N. P. A. D Gunasinghe (Author)
B. G Hollier (Author) - Queensland University of Technology
T Tanaka (Author) - Translational Research Institute
T Blick (Author) - Queensland University of Technology
A Toh (Author) - Queensland University of Technology
P Hill (Author) - The University of Melbourne
C Gilles (Author) - University of Liège
M Waltham (Author) - Queensland University of Technology
E. W Thompson (Author) - Queensland University of Technology
Publication details: Breast Cancer Research, Vol.19(1), pp.1-25
Publisher: BioMed Central Ltd.
Date published: 2017
DOI: 10.1186/s13058-017-0880-z
ISSN: 1465-542X
PMID: 28750639; PMC5530912
Copyright note: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Grant note: This work and EWT were supported in part by the EMPathy Breast Cancer Network (CG-10-04), a National Collaborative Research Program of the National Breast Cancer Foundation (Australia). This study benefited from support provided by the Victorian Government’s Operational Infrastructure Support Program to St. Vincent’s Institute.
Organisation Unit: School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99518707702621
Output Type: Journal article

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Web Of Science research areas: Oncology

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