Epithelial mesenchymal transition traits in human breast cancer cell lines

T Blick; E Widodo; H Hugo; M Waltham; M Lenburg; R M Neve; E W Thompson

doi:10.1007/s10585-008-9170-6

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Epithelial mesenchymal transition traits in human breast cancer cell lines

Journal article

Peer reviewed

Epithelial mesenchymal transition traits in human breast cancer cell lines

T Blick, E Widodo, H Hugo, M Waltham, M Lenburg, R M Neve and E W Thompson

Clinical & Experimental Metastasis, Vol.25(6), pp.629-642

2008

DOI: https://doi.org/10.1007/s10585-008-9170-6

PMID: 18461285

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Abstract

Basal

Biomedicine

Hematology

Luminal

Oncology

Cancer Research

Breast cancer

Surgical Oncology

EMT

Breast cancer stem cells

Biomedicine general

Mesenchymal

Epithelial mesenchymal transition (EMT) has long been associated with breast cancer cell invasiveness and evidence of EMT processes in clinical samples is growing rapidly. Genome-wide transcriptional profiling of increasingly larger numbers of human breast cancer (HBC) cell lines have confirmed the existence of a subgroup of cell lines (termed Basal B/Mesenchymal) with enhanced invasive properties and a predominantly mesenchymal gene expression signature, distinct from subgroups with predominantly luminal (termed Luminal) or mixed basal/luminal (termed Basal A) features (Neve et al Cancer Cell 2006). Studies providing molecular and cellular analyses of EMT features in these cell lines are summarised, and the expression levels of EMT-associated factors in these cell lines are analysed. Recent clinical studies supporting the presence of EMT-like changes in vivo are summarised. Human breast cancer cell lines with mesenchymal properties continue to hold out the promise of directing us towards key mechanisms at play in the metastatic dissemination of breast cancer.

Details

Title: Epithelial mesenchymal transition traits in human breast cancer cell lines
Authors: T Blick (Author) - St Vincents Institute of Medical Research
E Widodo (Author) - University of Melbourne
H Hugo (Author) - Murdoch Children's Research Institute
M Waltham (Author) - St Vincent's Hospital
M Lenburg (Author) - Boston University School of Medicine
R M Neve (Author) - Lawrence Berkeley National Laboratory
E W Thompson (Author) - University of Melbourne
Publication details: Clinical & Experimental Metastasis, Vol.25(6), pp.629-642
Publisher: Springer Netherlands
DOI: 10.1007/s10585-008-9170-6
ISSN: 1573-7276
PMID: 18461285
Organisation Unit: School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99518708102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Oncology

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