Journal article
Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression
Journal of Cellular Physiology, Vol.213(2), pp.374-383
2007
PMID: 17680632
Abstract
Like a set of bookends, cellular, molecular, and genetic changes of the beginnings of life mirror those of one of the most common cause of death--metastatic cancer. Epithelial to mesenchymal transition (EMT) is an important change in cell phenotype which allows the escape of epithelial cells from the structural constraints imposed by tissue architecture, and was first recognized by Elizabeth Hay in the early to mid 1980's to be a central process in early embryonic morphogenesis. Reversals of these changes, termed mesenchymal to epithelial transitions (METs), also occur and are important in tissue construction in normal development. Over the last decade, evidence has mounted for EMT as the means through which solid tissue epithelial cancers invade and metastasize. However, demonstrating this potentially rapid and transient process in vivo has proven difficult and data connecting the relevance of this process to tumor progression is still somewhat limited and controversial. Evidence for an important role of MET in the development of clinically overt metastases is starting to accumulate, and model systems have been developed. This review details recent advances in the knowledge of EMT as it occurs in breast development and carcinoma and prostate cancer progression, and highlights the role that MET plays in cancer metastasis. Finally, perspectives from a clinical and translational viewpoint are discussed.
Details
- Title
- Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression
- Authors
- Honor Hugo (Author) - Murdoch Childrens Research InstituteM Leigh Ackland (Author) - Deakin UniversityTony Blick (Author) - St Vincents Institute of Medical ResearchMitchell G Lawrence (Author) - Queensland University of TechnologyJudith A Clements (Author) - Monash UniversityElizabeth D Williams (Author) - Monash UniversityErik W Thompson (Author) - St Vincent's Hospital
- Publication details
- Journal of Cellular Physiology, Vol.213(2), pp.374-383
- Publisher
- John Wiley & Sons, Inc.
- DOI
- 10.1002/jcp.21223
- ISSN
- 1097-4652
- PMID
- 17680632
- Organisation Unit
- School of Health and Sport Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99518707902621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Cell Biology
- Physiology
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Source: InCites