Epigenetic analysis confirms no accelerated brain aging in schizophrenia

Joanne Voisey; Bruce R Lawford; C. Phillip Morris; Leesa F Wockner; Ernest P Noble; Ross Young; Divya Mehta

doi:10.1038/s41537-017-0026-4

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Epigenetic analysis confirms no accelerated brain aging in schizophrenia

Journal article

Open access

Peer reviewed

Epigenetic analysis confirms no accelerated brain aging in schizophrenia

Joanne Voisey, Bruce R Lawford, C. Phillip Morris, Leesa F Wockner, Ernest P Noble, Ross Young and Divya Mehta

n p j Schizophrenia, Vol.3, pp.1-3

2017

DOI: https://doi.org/10.1038/s41537-017-0026-4

PMCID: PMC5583345

PMID: 28871179

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Abstract

Epigenetic aging is associated with several biological mechanisms and diseases. We assessed two brain data sets, one small (n = 48) and one large (n = 392), to test epigenetic aging in schizophrenia. DNA methylation age from frontal cortex was significantly correlated with chronological age but no significant differences in DNA methylation age acceleration between schizophrenia cases and controls were observed in both data sets. Our results were consistent with a previous study investigating schizophrenia and epigenetic aging in superior temporal gyrus. Future studies targeting different brain regions and defined cell types are warranted to further investigate accelerated brain aging in schizophrenia.

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Title: Epigenetic analysis confirms no accelerated brain aging in schizophrenia
Authors: Joanne Voisey (Author) - Queensland University of Technology
Bruce R Lawford (Author) - Queensland University of Technology
C. Phillip Morris (Author) - Queensland University of Technology
Leesa F Wockner (Author) - QIMR Berghofer Medical Research Institute
Ernest P Noble (Author) - California State University Los Angeles
Ross Young (Author) - Queensland University of Technology
Divya Mehta (Author) - Queensland University of Technology
Publication details: n p j Schizophrenia, Vol.3, pp.1-3
Publisher: Nature Publishing Group
Date published: 2017
DOI: 10.1038/s41537-017-0026-4
ISSN: 2334-265X
PMID: 28871179; PMC5583345
Copyright note: (c) The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
Language: English
Record Identifier: 99550997702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

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