Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model

Kimberley E Stuart; Anna E King; Carmen M Fernandez-Martos; Mathew J Summers; James C Vickers

doi:10.1038/s41598-017-03016-0

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Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model

Journal article

Open access

Peer reviewed

Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model

Kimberley E Stuart, Anna E King, Carmen M Fernandez-Martos, Mathew J Summers and James C Vickers

Scientific Reports, Vol.7, 274

2017

DOI: https://doi.org/10.1038/s41598-017-03016-0

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Abstract

Alzheimer's disease

risk factors

stress and resilience

Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer's disease. A common familial Alzheimer's disease transgenic model showed heightened levels of the stress hormone, corticosterone. When exposed to periodic enhanced cognitive stimulation, these animals demonstrated further heightened levels of corticosterone as well as increased Aβ pathology. Hence, Alzheimer's disease may be associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, causing stimulatory environments to become stress-inducing, leading to a glucocorticoid-pathology cycle contributing to further Aβ release and plaque formation. This finding suggests that stimulation-based interventions and local environments for people with Alzheimer's disease need to be designed to minimise a stress response that may exacerbate brain pathology.

Details

Title: Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
Authors: Kimberley E Stuart (Author) - University of Tasmania
Anna E King (Author) - University of Tasmania
Carmen M Fernandez-Martos (Author) - University of Tasmania
Mathew J Summers (Author) - University of the Sunshine Coast - Faculty of Arts, Business and Law
James C Vickers (Author) - University of Tasmania
Publication details: Scientific Reports, Vol.7, 274; 7
Publisher: Nature Publishing Group
Date published: 2017
DOI: 10.1038/s41598-017-03016-0
ISSN: 2045-2322
Copyright note: Copyright © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Organisation Unit: School of Health; School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450910702621
Output Type: Journal article

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