Enterovirus71 (EV71) Utilise Host microRNAs to Mediate Host Immune System Enhancing Survival during Infection

Yan Long Edmund Lui; Tuan Lin Tan; Wee Hong Woo; Peter Timms; Louise Marie Hafner; Kian Hwa Tan; Eng Lee Tan

doi:10.1371/journal.pone.0102997

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Enterovirus71 (EV71) Utilise Host microRNAs to Mediate Host Immune System Enhancing Survival during Infection

Journal article

Open access

Peer reviewed

Enterovirus71 (EV71) Utilise Host microRNAs to Mediate Host Immune System Enhancing Survival during Infection

Yan Long Edmund Lui, Tuan Lin Tan, Wee Hong Woo, Peter Timms, Louise Marie Hafner, Kian Hwa Tan and Eng Lee Tan

PLoS One, Vol.9(7), e102997

2014

DOI: https://doi.org/10.1371/journal.pone.0102997

PMCID: PMC4105423

PMID: 25047717

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Abstract

enterovirus71 (EV71)

pathogenesis

Hand, Foot and Mouth Disease (HFMD) is a self-limiting viral disease that mainly affects infants and children. In contrast with other HFMD causing enteroviruses, Enterovirus71 (EV71) has commonly been associated with severe clinical manifestation leading to death. Currently, due to a lack in understanding of EV71 pathogenesis, there is no antiviral therapeutics for the treatment of HFMD patients. Therefore the need to better understand the mechanism of EV71 pathogenesis is warranted. We have previously reported a human colorectal adenocarcinoma cell line (HT29) based model to study the pathogenesis of EV71. Using this system, we showed that knockdown of DGCR8, an essential cofactor for microRNAs biogenesis resulted in a reduction of EV71 replication. We also demonstrated that there are miRNAs changes during EV71 pathogenesis and EV71 utilise host miRNAs to attenuate antiviral pathways during infection. Together, data from this study provide critical information on the role of miRNAs during EV71 infection.

Details

Title: Enterovirus71 (EV71) Utilise Host microRNAs to Mediate Host Immune System Enhancing Survival during Infection
Authors: Yan Long Edmund Lui (Author) - Queensland University of Technology
Tuan Lin Tan (Author) - Singapore Polytechnic, Singapore
Wee Hong Woo (Author) - Singapore Polytechnic, Singapore
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Louise Marie Hafner (Author) - Queensland University of Technology
Kian Hwa Tan (Author) - Singapore Polytechnic, Singapore
Eng Lee Tan (Author) - Singapore Polytechnic, Singapore
Publication details: PLoS One, Vol.9(7), e102997; 12
Publisher: Public Library of Science
Date published: 2014
DOI: 10.1371/journal.pone.0102997
ISSN: 1932-6203
PMID: 25047717; PMC4105423
Copyright note: Copyright © 2014 Lui et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449084602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology

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