Enhanced Gametocyte Formation in Erythrocyte Progenitor Cells: A Site-Specific Adaptation by Plasmodium falciparum

Christopher L Peatey; Jolanta A Watson; Katharine R Trenholme; Christopher L Brown; Lars Nielson; Marko Guenther; Nicholas Timmins; Gregory S Watson; Donald L Gardiner

doi:10.1093/infdis/jit309

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Enhanced Gametocyte Formation in Erythrocyte Progenitor Cells: A Site-Specific Adaptation by Plasmodium falciparum

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Enhanced Gametocyte Formation in Erythrocyte Progenitor Cells: A Site-Specific Adaptation by Plasmodium falciparum

Christopher L Peatey, Jolanta A Watson, Katharine R Trenholme, Christopher L Brown, Lars Nielson, Marko Guenther, Nicholas Timmins, Gregory S Watson and Donald L Gardiner

Journal of Infectious Diseases, Vol.208(4), pp.1170-1174

2013

DOI: https://doi.org/10.1093/infdis/jit309

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Abstract

Medical and Health Sciences

Biological Sciences

plasmodium falciparum

gametocytes

erythroid progenitor cells

atomic force microscopy

Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane elasticity, which may allow them to be retained within the bone marrow until maturation.

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Title: Enhanced Gametocyte Formation in Erythrocyte Progenitor Cells: A Site-Specific Adaptation by Plasmodium falciparum
Authors: Christopher L Peatey (Author) - Queensland Institute of Medical Research
Jolanta A Watson (Author) - James Cook University
Katharine R Trenholme (Author) - Queensland Institute of Medical Research
Christopher L Brown (Author) - Griffith University
Lars Nielson (Author) - University of Queensland
Marko Guenther (Author) - Centre for Regenerative Therapies, Germany
Nicholas Timmins (Author) - University of Queensland
Gregory S Watson (Author) - James Cook University
Donald L Gardiner (Author) - Queensland Institute of Medical Research
Publication details: Journal of Infectious Diseases, Vol.208(4), pp.1170-1174
Publisher: Oxford University Press
Date published: 2013
DOI: 10.1093/infdis/jit309
ISSN: 0022-1899; 0022-1899
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99449239902621
Output Type: Journal article

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