Journal article
Endothelium-Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions
Microcirculation, Vol.23(1), pp.15-32
2016
Abstract
Myocardial perfusion and coronary vascular resistance are regulated by signaling metabolites released from the local myocardium that act either directly on the VSMC or indirectly via stimulation of the endothelium. A prominent mechanism of vasodilation is EDH of the arteriolar smooth muscle, with EETs and H2O2 playing important roles in EDH in the coronary microcirculation. In some cases, EETs and H2O2 are released as transferable hyperpolarizing factors (EDHFs) that act directly on the VSMCs. By contrast, EETs and H2O2 can also promote endothelial KCa activity secondary to the amplification of extracellular Ca2+ influx and Ca2+ mobilization from intracellular stores, respectively. The resulting endothelial hyperpolarization may subsequently conduct to the media via myoendothelial gap junctions or potentially lead to the release of a chemically distinct factor(s). Furthermore, in human isolated coronary arterioles dilator signaling involving EETs and H2O2 may be integrated, being either complimentary or inhibitory depending on the stimulus. With an emphasis on the human coronary microcirculation, this review addresses the diverse and integrated mechanisms by which EETs and H2O2 regulate vessel tone and also examines the hypothesis that myoendothelial microdomain signaling facilitates EDH activity in the human heart.
Details
- Title
- Endothelium-Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions
- Authors
- David C Ellinsworth (Author) - University of Bristol, United KingdomShaun L Sandow (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringNilima Shukla (Author) - University of Bristol, United KingdomYanping Liu (Author)Jamie Y Jeremy (Author) - University of Bristol, United KingdomDavid D Gutterman (Author) - Medical College of Wisconsin, United States
- Publication details
- Microcirculation, Vol.23(1), pp.15-32
- Publisher
- John Wiley & Sons Ltd.
- Date published
- 2016
- DOI
- 10.1111/micc.12255
- ISSN
- 1073-9688
- Copyright note
- Copyright © 2016 The Authors. This is the accepted version of the following article: Ellinsworth DC, Sandow SL, Shukla N, Liu Y, Jeremy JY, Gutterman DD. Endothelium-derived hyperpolarization and coronary vasodilation: diverse and integrated roles of epoxyeicosatrienoic acids, hydrogen peroxide and gap junctions. Microcirculation 23: 15-32, 2016, which has been published in final form at http://dx.doi.org/10.1111/micc.12255.
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449944102621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Hematology
- Peripheral Vascular Disease
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Source: InCites