Journal article
Endothelial control of vasodilation: Integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids
Pfluegers Archiv: European Journal of Physiology, Vol.466(3), pp.389-405
2014
Abstract
Endothelium-derived epoxyeicosatrienoic acids (EETs) are fatty acid epoxides that play an important role in the control of vascular tone in selected coronary, renal, carotid, cerebral and skeletal muscle arteries. Vasodilation due to endothelium-dependent smooth muscle hyperpolarization (EDH) has been suggested to involve EETs as a transferable endothelium-derived hyperpolarizing factor. However, this activity may also be due to EETs interacting with the components of other primary EDH-mediated vasodilator mechanisms. Indeed, the transfer of hyperpolarization initiated in the endothelium to the adjacent smooth muscle via gap junction connexins occurs separately or synergistically with the release of K+ ions at discrete myoendothelial microdomain signalling sites. The net effects of such activity are smooth muscle hyperpolarization, closure of voltage-dependent Ca2+ channels, phospholipase C deactivation and vasodilation. The spatially localized and key components of the microdomain signalling complex are the inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum Ca2+ store, Ca2+-activated K+ (KCa), transient receptor potential (TRP) and inward-rectifying K+ channels, gap junctions and the smooth muscle Na+/K+-ATPase. Of these, TRP channels and connexins are key endothelial effector targets modulated by EETs. In an integrated manner, endogenous EETs enhance extracellular Ca 2+ influx (thereby amplifying and prolonging KCa-mediated endothelial hyperpolarization) and also facilitate the conduction of this hyperpolarization to spatially remote vessel regions. The contribution of EETs and the receptor and channel subtypes involved in EDH-related microdomain signalling, as a candidate for a universal EDH-mediated vasodilator mechanism, vary with vascular bed, species, development and disease and thus represent potentially selective targets for modulating specific artery function. © 2013 Springer-Verlag Berlin Heidelberg.
Details
- Title
- Endothelial control of vasodilation: Integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids
- Authors
- D C Ellinsworth (Author) - University Bristol, United KingdomS Earley (Author) - Colorado State University, United StatesT V Murphy (Author) - University of New South WalesShaun L Sandow (Author) - University of New South Wales
- Publication details
- Pfluegers Archiv: European Journal of Physiology, Vol.466(3), pp.389-405
- Publisher
- Springer
- Date published
- 2014
- DOI
- 10.1007/s00424-013-1303-3
- ISSN
- 0031-6768
- Copyright note
- Copyright © Springer-Verlag 2012. The author's accepted version is reproduced here in accordance with the publisher's copyright policy. The final publication is available at www.springerlink.com
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449098502621
- Output Type
- Journal article
Metrics
131 File views/ downloads
672 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Physiology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites