Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship

Peter J Little; Christopher D Askew; Suowen Xu; Danielle Kamato

doi:10.3390/biomedicines9060699

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Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship

Journal article

Open access

Peer reviewed

Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship

Peter J Little, Christopher D Askew, Suowen Xu and Danielle Kamato

Biomedicines, Vol.9(6), pp.1-9

2021

DOI: https://doi.org/10.3390/biomedicines9060699

PMCID: PMC8234001

PMID: 34203043

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Abstract

endothelium

atherosclerosis

complications

nitric oxide

endothelin

plethysmography

The endothelium is the single-cell monolayer that lines the entire vasculature. The endothelium has a barrier function to separate blood from organs and tissues but also has an increasingly appreciated role in anti-coagulation, vascular senescence, endocrine secretion, suppression of inflammation and beyond. In modern times, endothelial cells have been identified as the source of major endocrine and vaso-regulatory factors principally the dissolved lipophilic vosodilating gas, nitric oxide and the potent vascular constricting G protein receptor agonists, the peptide endothelin. The role of the endothelium can be conveniently conceptualized. Continued investigations of the mechanism of endothelial dysfunction will lead to novel therapies for cardiovascular disease. In this review, we discuss the impact of endothelial dysfunction on cardiovascular disease and assess the clinical relevance of endothelial dysfunction.

Details

Title: Endothelial Dysfunction and Cardiovascular Disease: History and Analysis of the Clinical Utility of the Relationship
Authors: Peter J Little (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Christopher D Askew (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Suowen Xu (Author) - University of Science and Technology of China
Danielle Kamato (Author) - The University of Queensland
Publication details: Biomedicines, Vol.9(6), pp.1-9
Publisher: MDPI AG
Date published: 2021
DOI: 10.3390/biomedicines9060699
ISSN: 2227-9059
PMID: 34203043; PMC8234001
Copyright note: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Grants: Characterising the mechanism between periodontal disease and the onset of cardiovascular disease, 1160925, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: National Heart Foundation of Australia (102129)
Organisation Unit: School of Health; Cancer Research Cluster; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99545008402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Medicine, Research & Experimental; Pharmacology & Pharmacy

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