Emotional processing, P50 sensory gating, and social functioning in bipolar disorder

L Vuillier; Daniel F Hermens; K Chitty; C Wang; M Kaur; P B Ward; R Degabriele; I B Hickie; Jim Lagopoulos

doi:10.1177/1550059414523417

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Emotional processing, P50 sensory gating, and social functioning in bipolar disorder

Journal article

Open access

Peer reviewed

Emotional processing, P50 sensory gating, and social functioning in bipolar disorder

L Vuillier, Daniel F Hermens, K Chitty, C Wang, M Kaur, P B Ward, R Degabriele, I B Hickie and Jim Lagopoulos

Clinical EEG and Neuroscience, Vol.46(2), pp.81-87

2015

DOI: https://doi.org/10.1177/1550059414523417

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Abstract

auditory sensory gating

bipolar disorder

emotion

P50

social functioning

Emotional processing has been reported to effect sensory gating as measured by the event-related potential known as P50. Because both P50 and emotional processing are dysfunctional in bipolar disorder (BD), we sought to investigate the impact that concurrent emotional processing has on sensory gating in this psychiatric population. P50 was recorded using a paired-click paradigm. Peak-to-peak amplitudes for stimulus 1 (S1) and stimulus 2 (S2) were acquired during the presentation of disgust and neutral faces to young adults with BD (n = 19) and controls (n = 20). Social functioning and quality-of-life self-reported measures were also obtained. The BD group had significantly larger P50 amplitudes elicited by the S2-disgust response compared with controls, but no significant difference in overall P50 sensory gating was found between the groups. There were also no differences between groups in S1-disgust or in either of the neutral P50 amplitudes. The BD group showed significant associations between sensory gating to disgust and measures of social functioning. Importantly, BD showed impaired filtering of auditory information when paired with an emotionally salient image. Thus, it appears that patients with the greatest impairment in sensory gating also have the most difficulty engaging in social situations. © EEG and Clinical Neuroscience Society (ECNS) 2014.

Details

Title: Emotional processing, P50 sensory gating, and social functioning in bipolar disorder
Authors: L Vuillier (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
K Chitty (Author) - University of Sydney
C Wang (Author) - University of Sydney
M Kaur (Author) - University of Sydney
P B Ward (Author) - University of New South Wales
R Degabriele (Author) - University of New South Wales
I B Hickie (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
Publication details: Clinical EEG and Neuroscience, Vol.46(2), pp.81-87
Publisher: Sage Publications Inc.
Date published: 2015
DOI: 10.1177/1550059414523417
ISSN: 1550-0594
Copyright note: Copyright © 2015 The Authors. Reprinted by permission of SAGE Publications. Vuillier, L; Hermens, D F; Chitty, K; Wang, C; Kaur, M; Ward, P B; Degabriele, R; Hickie, I B; Lagopoulos, Jim, Emotional processing, P50 sensory gating, and social functioning in bipolar disorder, Clinical EEG and Neuroscience (46:2) pp. 81-87.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449279102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neuroimaging; Neurosciences; Psychiatry; Psychology

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