Emergence of Burkholderia pseudomallei Sequence Type 562, Northern Australia

Ella M Meumann; Mirjam Kaestli; Mark Mayo; Linda Ward; Audrey Rachlin; Jessica R Webb; Mariana Kleinecke; Erin P Price; Bart J Currie

doi:10.3201/eid2704.202716

Back

Emergence of Burkholderia pseudomallei Sequence Type 562, Northern Australia

Journal article

Peer reviewed

Emergence of Burkholderia pseudomallei Sequence Type 562, Northern Australia

Ella M Meumann, Mirjam Kaestli, Mark Mayo, Linda Ward, Audrey Rachlin, Jessica R Webb, Mariana Kleinecke, Erin P Price and Bart J Currie

Emerging Infectious Diseases, Vol.27(4), pp.1057-1067

2021

DOI: https://doi.org/10.3201/eid2704.202716

PMID: 33754984

Files and links (1)

url

https://doi.org/10.3201/eid2704.202716View

Published Version Open

Abstract

Epidemiology

Genomics

bacteria

ST562

phylogenetics

Burkholderia pseudomallei

melioidosis

sequence type

Australia

Since 2005, the range of Burkholderia pseudomallei sequence type 562 (ST562) has expanded in northern Australia. During 2005-2019, ST562 caused melioidosis in 61 humans and 3 animals. Cases initially occurred in suburbs surrounding a creek before spreading across urban Darwin, Australia and a nearby island community. In urban Darwin, ST562 caused 12% (53/440) of melioidosis cases, a proportion that increased during the study period. We analyzed 2 clusters of cases with epidemiologic links and used genomic analysis to identify previously unassociated cases. We found that ST562 isolates from Hainan Province, China, and Pingtung County, Taiwan, were distantly related to ST562 strains from Australia. Temporal genomic analysis suggested a single ST562 introduction into the Darwin region in ≈1988. The origin and transmission mode of ST562 into Australia remain uncertain.

Details

Title: Emergence of Burkholderia pseudomallei Sequence Type 562, Northern Australia
Authors: Ella M Meumann (Author) - Menzies School of Health Research
Mirjam Kaestli (Author) - Menzies School of Health Research
Mark Mayo (Author) - Menzies School of Health Research
Linda Ward (Author) - Menzies School of Health Research
Audrey Rachlin (Author) - Menzies School of Health Research
Jessica R Webb (Author) - Menzies School of Health Research
Mariana Kleinecke (Author) - Menzies School of Health Research
Erin P Price (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Bart J Currie (Author) - Menzies School of Health Research
Publication details: Emerging Infectious Diseases, Vol.27(4), pp.1057-1067
Publisher: US Department of Health and Human Services, Centers for Disease Control and Prevention
Date published: 2021
DOI: 10.3201/eid2704.202716
ISSN: 1080-6059; 1080-6040
PMID: 33754984
Grants: The Darwin Perspective Melioidosis Study: Years 27-31, 1098337, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Improving Health Outcomes in the Tropical North: A Multidisciplinary Collaboration, 1131932, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: Australian National Health and Medical Research Council (grant nos. 1046812). E.P.P. was funded by an Advance Queensland fellowship (grant no. AQIRF0362018). E.M.M. was funded by a postgraduate scholarship from the Australian National Health and Medical Research Council (grant no. 1114696).
Organisation Unit: Centre for Bioinnovation
Language: English
Record Identifier: 99522508402621
Output Type: Journal article

Metrics

31 Record Views

12 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites