Elucidating the host–pathogen interaction between human colorectal cells and invading enterovirus71 using transcriptomics profiling

Yan Long Edmund Lui; Tuan Lin Tan; Peter Timms; Louise Marie Hafner; Kian Hwa Tan; Eng Lee Tan

doi:10.1016/j.fob.2014.04.005

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Elucidating the host–pathogen interaction between human colorectal cells and invading enterovirus71 using transcriptomics profiling

Journal article

Open access

Peer reviewed

Elucidating the host–pathogen interaction between human colorectal cells and invading enterovirus71 using transcriptomics profiling

Yan Long Edmund Lui, Tuan Lin Tan, Peter Timms, Louise Marie Hafner, Kian Hwa Tan and Eng Lee Tan

FEBS Open Bio, Vol.4, pp.426-431

2014

DOI: https://doi.org/10.1016/j.fob.2014.04.005

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Abstract

enterovirus71

transcriptomics

microarray

mRNA profiling

colorectal cells

hand

foot and mouth disease

Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD) and has been shown to be associated with severe clinical manifestation. Currently, there is no antiviral therapeutic for the treatment of HFMD patients owing to a lack of understanding of EV71 pathogenesis,. This study seeks to elucidate the transcriptomic changes that result from EV71 infection. Human whole genome microarray was employed to monitor changes in genomic profiles between infected and uninfected cells. The results reveal altered expression of human genes involved in critical pathways including the immune response and the stress response. Together, data from this study provide valuable insights into the host-pathogen interaction between human colorectal cells and EV71.

Details

Title: Elucidating the host–pathogen interaction between human colorectal cells and invading enterovirus71 using transcriptomics profiling
Authors: Yan Long Edmund Lui (Author) - Queensland University of Technology
Tuan Lin Tan (Author) - Singapore Polytechnic, Singapore
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Louise Marie Hafner (Author) - Queensland University of Technology
Kian Hwa Tan (Author) - Singapore Polytechnic, Singapore
Eng Lee Tan (Author) - Singapore Polytechnic, Singapore
Publication details: FEBS Open Bio, Vol.4, pp.426-431
Publisher: Elsevier BV
Date published: 2014
DOI: 10.1016/j.fob.2014.04.005
ISSN: 2211-5463
Copyright note: Copyright © 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. Thisis an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/)
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99448868602621
Output Type: Journal article

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Web Of Science research areas: Biochemistry & Molecular Biology

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