Journal article
Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in a rat model
The Journal of Physiology, Vol.597(13), pp.3349-3361
2019
PMID: 31124126
Abstract
Dietary intakes of linoleic acid (LA) have increased dramatically in Western populations, including in women of reproductive age. Pro-inflammatory effects of LA may have detrimental effects on maternal and offspring outcomes. We aimed to investigate whether consumption of a maternal diet with elevated LA altered maternal inflammatory or metabolic markers during pregnancy, fetal growth and/or the sex ratio of the offspring. Female Wistar Kyoto rats consumed a diet high in LA (HLA) (6.21% of energy) or a diet low in LA (LLA) (1.44% of energy) for 10 weeks prior to mating and during pregnancy. Pregnant rats were killed at embryonic day 20 (E20). There were no differences in maternal or fetal body weights or organ weights in the HLA group compared to the LLA group. There was no difference in maternal circulating cytokine concentrations between dietary groups. In the maternal liver, IL-1 alpha concentrations were significantly lower, and TNF-alpha and IL-7 significantly higher in the HLA group. Total plasma cholesterol, LDL-cholesterol, HDL cholesterol and the total:HDL cholesterol ratio were lower in dams fed the HLA diet. mRNA expression of sterol regulatory element binding transcription factor 1 (SREBF-1) and leptin in maternal adipose tissue was lower in the HLA group, as were circulating leptin concentrations. The proportion of male fetuses was lower and circulating prostaglandin E metabolite concentrations were increased in the HLA group. In conclusion, consumption of a maternal diet high in linoleic acid alters cholesterol metabolism and prostaglandin E metabolite concentrations, which may contribute to the reduced proportion of male offspring.
Details
- Title
- Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in a rat model
- Authors
- Nirajan Shrestha (Author) - Griffith UniversityJames S. M. Cuffe (Author) - Griffith UniversityOlivia J. Holland (Author) - Griffith UniversityAndrew C. Bulmer (Author) - Griffith UniversityMelissa Hill (Author) - Griffith UniversityAnthony V. Perkins (Author) - Griffith UniversityBeverly S. Muhlhausler (Author) - University of AdelaideAndrew J. McAinch (Author) - Victoria UniversityDeanne H. Hryciw (Author) - Griffith University
- Publication details
- The Journal of Physiology, Vol.597(13), pp.3349-3361
- Publisher
- Wiley-Blackwell Publishing Ltd.
- DOI
- 10.1113/JP277583
- ISSN
- 1469-7793
- PMID
- 31124126
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99685195602621
- Output Type
- Journal article
Metrics
28 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Neurosciences
- Physiology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites