Journal article
Elemental metabolomics in human cord blood: Method validation and trace element quantification
Journal of Trace Elements in Medicine and Biology, Vol.59, pp.1-10
2020
PMID: 31711786
Abstract
Trace elements are an essential requirement for human health and development and changes in trace element status have been associated with pregnancy complications such as gestational diabetes mellitus (GDM), pre-eclampsia (PE), fetal growth restriction (FGR), and preterm birth. Elemental metabolomics, which involves the simultaneous quantification and characterisation of multiple elements, could provide important insights into these gestational disorders.
This study used an Agilent 7900 inductively coupled plasma mass spectrometer (ICP-MS) to simultaneously measure 68 elements, in 166 placental cord blood samples collected from women with various pregnancy complications (control, hypertensive, PE, GDM, FGR, pre-term, and post-term birth).
There were single element differences across gestational outcomes for elements Mg, P, Cr, Ni, Sr, Mo, I, Au, Pb, and U. Hypertensive and post-term pregnancies were significantly higher in Ni concentrations when compared to controls (control = 2.74 μg/L, hypertensive = 6.72 μg/L, post-term = 7.93 μg/L, p < 0.05), iodine concentration was significantly higher in post-term pregnancies (p < 0.05), and Pb concentrations were the lowest in pre-term pregnancies (pre-term = 2.79 μg/L, control = 4.68 μg/L, PE = 5.32 μg/L, GDM = 8.27 μg/L, p < 0.01). Further analysis was conducted using receiver operating characteristic (ROC) curves for differentiating pregnancy groups. The ratio of Sn/Pb showed the best diagnostic power in discriminating between control and pre-term birth with area under the curve (AUC) 0.86. When comparing control and post-term birth, Mg/Cr (AUC = 0.84), and Cr (AUC = 0.83) had the best diagnostic powers. In pre-term and post-term comparisons Ba was the best single element (81.5%), and P/Cu provided the best ratio (91.7%).
This study has shown that analysis of multiple elements can enable differentiation between fetal cord blood samples from control, hypertensive, PE, GDM, FGR, pre and post-term pregnancies. This data highlights the power of elemental metabolomics and provides a basis for future gestational studies.
Details
- Title
- Elemental metabolomics in human cord blood: Method validation and trace element quantification
- Authors
- Daniel R. McKeating (Author) - Griffith UniversityJoshua J. Fisher (Author) - Griffith UniversityPing Zhang (Author) - Griffith UniversityWilliam W. Bennett (Author) - Griffith UniversityAnthony V. Perkins (Corresponding Author) - Griffith University
- Publication details
- Journal of Trace Elements in Medicine and Biology, Vol.59, pp.1-10
- Publisher
- Elsevier GmbH
- DOI
- 10.1016/j.jtemb.2019.126419
- ISSN
- 1878-3252
- PMID
- 31711786
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99685197902621
- Output Type
- Journal article
Metrics
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- Web Of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
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Source: InCites