Journal article
Elemental Metabolomics for Prediction of Term Gestational Outcomes Utilising 18-Week Maternal Plasma and Urine Samples
Biological Trace Element Research, Vol.199(1), pp.26-40
2021
PMID: 32239374
Abstract
A normal pregnancy is essential to establishing a healthy start to life. Complications during have been associated with adverse perinatal outcomes and lifelong health problems. The ability to identify risk factors associated with pregnancy complications early in gestation is vitally important for preventing negative foetal outcomes. Maternal nutrition has been long considered vital to a healthy pregnancy, with micronutrients and trace elements heavily implicated in maternofoetal metabolism. This study proposed the use of elemental metabolomics to study multiple elements at 18 weeks gestation from blood plasma and urine to construct models that could predict outcomes such as small for gestational age (SGA) (n = 10), low placental weight (n = 18), and preterm birth (n = 13) from control samples (n = 87). Samples collected from the Lyell McEwin Hospital in Adelaide, South Australia, were measured for 27 plasma elements and 37 urine elements by inductively coupled plasma mass spectrometry. Exploratory analysis indicated an average selenium concentration 20 mu g/L lower than established reference ranges across all groups, low zinc in preterm (0.64 mu g/L, reference range 0.66-1.10 mu g/L), and higher iodine in preterm and SGA gestations (preterm 102 mu g/L, SGA 111 mu g/L, reference range 40-92 mu g/L). Using random forest algorithms with receiver operating characteristic curves, low placental weight was predicted with 86.7% accuracy using plasma, 78.6% prediction for SGA with urine, and 73.5% determination of preterm pregnancies. This study indicates that elemental metabolomic modelling could provide a means of early detection of at-risk pregnancies allowing for more targeted monitoring of mothers, with potential for early intervention strategies to be developed.
Details
- Title
- Elemental Metabolomics for Prediction of Term Gestational Outcomes Utilising 18-Week Maternal Plasma and Urine Samples
- Authors
- Daniel R. McKeating (Author) - Griffith UniversityVicki L. Clifton (Author) - University of QueenslandCameron P. Hurst (Author) - QIMR Berghofer Medical Research InstituteJoshua J. Fisher (Author) - Griffith UniversityWilliam W. Bennett (Author) - Griffith UniversityAnthony Perkins (Corresponding Author) - Griffith University
- Publication details
- Biological Trace Element Research, Vol.199(1), pp.26-40
- Publisher
- Springer
- DOI
- 10.1007/s12011-020-02127-6
- ISSN
- 1559-0720
- PMID
- 32239374
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99685195702621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
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