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Published VersionCC BY V4.0, Open Access
Journal article
Elemental Metabolomics and Pregnancy Outcomes
Nutrients, Vol.11(1), pp.1-18
2019
PMCID: PMC6356574
PMID: 30609706
Abstract
Trace elements are important for human health and development. The body requires specific micronutrients to function, with aberrant changes associated with a variety of negative health outcomes. Despite this evidence, the status and function of micronutrients during pregnancy are relatively unknown and more information is required to ensure that women receive optimal intakes for foetal development. Changes in trace element status have been associated with pregnancy complications such as gestational diabetes mellitus (GDM), pre-eclampsia (PE), intrauterine growth restriction (IUGR), and preterm birth. Measuring micronutrients with methodologies such as elemental metabolomics, which involves the simultaneous quantification and characterisation of multiple elements, could provide insight into gestational disorders. Identifying unique and subtle micronutrient changes may highlight associated proteins that are affected underpinning the pathophysiology of these complications, leading to new means of disease diagnosis. This review will provide a comprehensive summary of micronutrient status during pregnancy, and their associations with gestational disorders. Furthermore, it will also comment on the potential use of elemental metabolomics as a technique for disease characterisation and prediction.
Details
- Title
- Elemental Metabolomics and Pregnancy Outcomes
- Authors
- Daniel R. McKeating (Author) - Griffith UniversityJoshua J. Fisher (Author) - Griffith UniversityAnthony V. Perkins (Corresponding Author) - Griffith University
- Publication details
- Nutrients, Vol.11(1), pp.1-18
- Publisher
- MDPI AG
- Date published
- 2019
- DOI
- 10.3390/nu11010073
- ISSN
- 2072-6643
- PMID
- 30609706; PMC6356574
- Copyright note
- © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685296302621
- Output Type
- Journal article
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