Journal article
Electrophysiological phenotypes of suicidality predict prolonged response to oral ketamine treatment
Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol.123, pp.1-10
2023
PMID: 36565983
Abstract
Oral ketamine has shown to be a rapid-acting antidepressant and a potential treatment option for suicidality, however, repeated doses are often required. Objective markers of prolonged treatment response are needed to help individuals and clinicians make informed treatment decisions. This secondary analysis sought to identify objective electrophysiological predictors of both prolonged response and dose sensitivity to low-dose oral ketamine in people with chronic suicidality. Individuals with a Beck Scale for Suicide Ideation total score (BSS) ≥ 6 (N = 29) completed a six-week ketamine treatment, pre-treatment electroencephalography and follow-up assessment of suicidality (four weeks from the final ketamine dose). Prolonged response was observed in 52% of participants (follow-up BSS reduced by 50% or ≤6); nearly half were prolonged non-responders. There was decisive evidence for a predictive Bayesian linear regression model with follow-up BSS score as the response variable and pre-treatment auditory evoked power bands as predictors (theta, alpha and beta frequencies, BF10 = 17,948, R2 = 0.70). A Bayesian one-way ANOVA indicated strong evidence for a model of positive association between auditory evoked power and ketamine dose sensitivity (theta-alpha BF+0 = 108, effect size δ = 1.3, 95% CI 0.5–2.1; high-beta BF+0 = 7.4, δ = 0.8, 95% CI 0.1–1.6). Given auditory evoked power may index serotonin neurotransmission, these results suggest that a prolonged response to ketamine may, in part, be mediated by pre-treatment serotonergic functioning. In addition, the observed beta power differences may arise from GABAergic functioning. These suicidality phenotypes, identifiable by pre-treatment electrophysiology, may aid diagnosis, treatment selection and prediction of prolonged treatment outcome.
Details
- Title
- Electrophysiological phenotypes of suicidality predict prolonged response to oral ketamine treatment
- Authors
- Adem T Can (Author) - University of the Sunshine Coast, Queensland, Thompson InstitutePaul E Schwenn (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteBen Isbel (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDenise Beaudequin (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAna P Bouças (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMegan Dutton (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMonique Jones (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteCyrana C Gallay (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteGrace Forsyth (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMaxwell R Bennett (Author) - University of SydneyJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F Hermens (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol.123, pp.1-10
- Publisher
- Elsevier Inc.
- DOI
- 10.1016/j.pnpbp.2022.110701
- ISSN
- 1878-4216
- PMID
- 36565983
- Organisation Unit
- Centre for Human Factors and Sociotechnical Systems; Graduate Research School; Sustainability Research Centre; School of Law and Society; Thompson Institute
- Language
- English
- Record Identifier
- 99695750002621
- Output Type
- Journal article
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- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry
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