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Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit - hyperactivity disorder - A randomized controlled trial322.18 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: A randomized controlled trial
Nutrition, Vol.28(6), pp.670-677
2012
PMID: 22541055
Abstract
To determine the effects of an eicosapentaenoic acid (EPA)–rich oil and a docosahexaenoic acid (DHA)–rich oil versus an ω-6 polyunsaturated fatty acid–rich safflower oil (control) on literacy and behavior in children with attention-deficit/hyperactivity disorder (ADHD) in a randomized controlled trial.
Supplements rich in EPA, DHA, or safflower oil were randomly allocated for 4 mo to 90 Australian children 7 to 12 y old with ADHD symptoms higher than the 90th percentile on the Conners Rating Scales. The effect of supplementation on cognition, literacy, and parent-rated behavior was assessed by linear mixed modeling. Pearson correlations determined associations between the changes in outcome measurements and the erythrocyte fatty acid content (percentage of total) from baseline to 4 mo.
There were no significant differences between the supplement groups in the primary outcomes after 4 mo. However, the erythrocyte fatty acid profiles indicated that an increased proportion of DHA was associated with improved word reading (r = 0.394) and lower parent ratings of oppositional behavior (r = 0.392). These effects were more evident in a subgroup of 17 children with learning difficulties: an increased erythrocyte DHA was associated with improved word reading (r = 0.683), improved spelling (r = 0.556), an improved ability to divide attention (r = 0.676), and lower parent ratings of oppositional behavior (r = 0.777), hyperactivity (r = 0.702), restlessness (r = 0.705), and overall ADHD symptoms (r = 0.665).
Increases in erythrocyte ω-3 polyunsaturated fatty acids, specifically DHA, may improve literacy and behavior in children with ADHD. The greatest benefit may be observed in children who have comorbid learning difficulties.
Details
- Title
- Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: A randomized controlled trial
- Authors
- Catherine M Milte (Author) - University of South AustraliaNatalie Parletta (Author) - University of South AustraliaJonathan D Buckley (Author) - University of South AustraliaAlison M Coates (Author) - University of South AustraliaRoss Young (Author) - Queensland University of TechnologyPeter R.C Howe (Author) - Australian Technology Network Centre for Metabolic Fitness
- Publication details
- Nutrition, Vol.28(6), pp.670-677
- Publisher
- Elsevier Inc.
- Date published
- 2012
- DOI
- 10.1016/j.nut.2011.12.009
- ISSN
- 1873-1244; 0899-9007
- PMID
- 22541055
- Copyright note
- Copyright © 2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550997802621
- Output Type
- Journal article
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