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Journal article
Efficacy and Safety of Thalidomide As a Pre-Medication of Chemotherapy-Induced Nausea and Vomiting (CINV) Following Highly Emetogenic Chemotherapy (HEC): A Systematic Review and Meta-Analysis
Frontiers in Oncology, Vol.11, pp.1-11
2022
PMID: 35141156
Abstract
Background: In China, thalidomide (THD) has been used to prevent chemotherapy-induced nausea and vomiting (CINV) following highly emetogenic chemotherapy (HEC); however, there is limited evidence on the efficacy and safety of THD in this setting. The aim of this study was to evaluate the efficacy, safety, and impact on quality of life (QoL) of THD on CINV following HEC.
Methods: Electronic databases were systematically searched for all randomized controlled trials (RCTs) in HEC using THD. The primary outcomes were complete response (CR) and no nausea, Secondary outcomes were the incidence of adverse events and QoL related indicators. We calculated risk ratios (RRs) and 95% confidence intervals (CIs) using a fixed-effects model. In the case of heterogeneity (I2≥50%), a random-effects model was performed.
Results: A total of 3168 patients were included from 34 RCTs. In terms of CR rate, THD plus 5-HT3 receptor antagonist (5-HT3RA) with or without dexamethasone (DEX) was significantly higher than 5-HT3RA with or without DEX in the acute phase (74.4% vs 67.4%; RR 1.10), delayed phase (70.6% vs 50.4%; RR 1.53), and overall phase (68.4% vs 53.4%; RR 1.28). In terms of no nausea rate, the THD group was also significantly higher than the control group in the acute phase (61.7% vs 55.5%; RR 1.12), delayed phase (50.5% vs 30.0%; RR 1.69), and overall phase (44.6% vs 29.9%; RR 1.50). There was no statistical difference in the incidence of fatigue, headache, diarrhea, rash, hepatorenal damage, and myelosuppression between those with and without THD. The incidence of increase in KPS scores, weight gain, appetite improvement, and sleep quality improvement were significantly higher with the addition of THD.
Conclusions: THD may be effective and safe for the prevention of CINV patients treated with HEC and may improve QoL.
Details
- Title
- Efficacy and Safety of Thalidomide As a Pre-Medication of Chemotherapy-Induced Nausea and Vomiting (CINV) Following Highly Emetogenic Chemotherapy (HEC): A Systematic Review and Meta-Analysis
- Authors
- Jiyi Xie - Huazhong University of Science and TechnologyCong Zhang - Huazhong University of Science and TechnologyShijun Li - Huazhong University of Science and TechnologyRong Dai - Huazhong University of Science and TechnologyMitchell A Sullivan - The University of QueenslandBin Deng - Huazhong University of Science and TechnologyQiling Xu - Huazhong University of Science and TechnologyChen Shi (Corresponding Author) - Huazhong University of Science and TechnologyYu Zhang (Corresponding Author) - Huazhong University of Science and Technology
- Publication details
- Frontiers in Oncology, Vol.11, pp.1-11
- Publisher
- Frontiers Research Foundation
- Date published
- 2022
- DOI
- 10.3389/fonc.2021.818839
- ISSN
- 2234-943X
- PMID
- 35141156
- Copyright note
- © 2022 Xie, Zhang, Li, Dai, Sullivan, Deng, Xu, Wang, Shi and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Data Availability
- The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding authors.
- Grant note
- This work was supported by the National Natural Science Foundation of China [82073402] and Key research and development program of Hubei Province [2020BCA060].
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035094002621
- Output Type
- Journal article
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