Effects of azithromycin on ozone-induced airway neutrophilia and cytokine release

G I Criqui; Colin Solomon; B S Welch; R E Ferrando; H A Boushey; J Balmes

doi:10.1034/j.1399-3003.2000.15e08.x

Back

Effects of azithromycin on ozone-induced airway neutrophilia and cytokine release

Journal article

Peer reviewed

Effects of azithromycin on ozone-induced airway neutrophilia and cytokine release

G I Criqui, Colin Solomon, B S Welch, R E Ferrando, H A Boushey and J Balmes

European Respiratory Journal, Vol.15(5), pp.856-862

2000

DOI: https://doi.org/10.1034/j.1399-3003.2000.15e08.x

Files and links (1)

url

https://doi.org/10.1034/j.1399-3003.2000.15e08.xView

Published Version

Abstract

Medical and Health Sciences

interleukin-8

macrolide antibiotics

neutrophils

Exposure of humans to ozone causes increased neutrophils and inflammatory cytokines in airway lining fluid. Recent research shows that macrolide antibiotics may reduce interleukin (IL)-8 production by bronchial epithelial cells and inhibit neutrophil chemotaxis. A double-blind, cross-over study was performed in which 12 healthy subjects underwent two separate 4-h exposures to 0.2 parts per million ozone while exercising intermittently. In the 73.5 h before exposure, subjects were pretreated with either 1,250 mg azithromycin or placebo. Sputum induction conducted 74 h pre- and 18 h post-exposure was used to measure total cells, per cent neutrophils, IL-6, and IL-8. There were significant (p less than 0.05) pre- to post-exposure increases in total cells, neutrophils, IL-6 and IL-8 in both the azithromycin and placebo arms. However, no significant differences were found between azithromycin and placebo conditions in the post- minus pre-exposure value for these variables. The results suggest that in healthy subjects, in the design used, azithromycin, in usual clinical doses, does not have anti-inflammatory effects on human airways as indicated in the measured variables.

Details

Title: Effects of azithromycin on ozone-induced airway neutrophilia and cytokine release
Authors: G I Criqui (Author) - University of California, United States
Colin Solomon (Author) - University of California, United States
B S Welch (Author) - University of California, United States
R E Ferrando (Author) - University of California, United States
H A Boushey (Author) - University of California, United States
J Balmes (Author) - University of California, United States
Publication details: European Respiratory Journal, Vol.15(5), pp.856-862
Publisher: European Respiratory Society
Date published: 2000
DOI: 10.1034/j.1399-3003.2000.15e08.x
ISSN: 0903-1936
Organisation Unit: Centre for Human Factors and Systems Science; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450494402621
Output Type: Journal article

Metrics

4 File views/ downloads

496 Record Views

16 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Web Of Science research areas: Respiratory System

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites