Journal article
Effects of active ingredients from traditional Chinese medicines on glycogen molecular structure in diabetic mice
European Polymer Journal, Vol.112, pp.67-72
2019
Abstract
Glycogen, a complex branched glucose polymer, is a blood-sugar reservoir; it comprises β particles (∼20 nm in size), which can link together into larger (>40 nm) α particles. In type 2 diabetic mice, liver-glycogen α particles are fragile, degrading into β particles in the presence of a hydrogen-bond disruptor (dimethyl sulfoxide); this is detected by analyzing the molecular structure (the weight distribution as a function of molecular size) with size-exclusion chromatography (a type of gel-permeation chromatography, GPC). The β particles quickly degrade enzymatically to glucose, with implications for diabetic hyperglycemia. We examine if this fragility is altered by using active ingredients from traditional Chinese medicines (TCMs) with proven efficacy for managing some diabetes symptoms. Glycogen molecular structural differences between astragalus polysaccharide (APS), berberine (BBR), panax notoginseng saponins (PNS) and pueraria flavonoid (PF)-treated and untreated diabetic mouse glycogen were studied. With APS, BBR and PF, the glycogen showed no significant fragility: effective medication can strengthen impaired glycogen fragility in diabetes. This may provide a new way to check the efficacy of individual components of TCM and to explore drug targets for diabetes.
Details
- Title
- Effects of active ingredients from traditional Chinese medicines on glycogen molecular structure in diabetic mice
- Authors
- Cheng Li - Yangzhou UniversityHua Gan - Huazhong University of Science and TechnologyXinle Tan - University of QueenslandZhenxia Hu - Wuhan UniversityBin Deng - Huazhong University of Science and TechnologyMitchell A Sullivan - University of QueenslandRobert G Gilbert (Corresponding Author) - University of Queensland
- Publication details
- European Polymer Journal, Vol.112, pp.67-72
- Publisher
- Elsevier Ltd
- Date published
- 2019
- DOI
- 10.1016/j.eurpolymj.2018.12.039
- ISSN
- 1873-1945
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035096202621
- Output Type
- Journal article
Metrics
3 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Polymer Science
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites