Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study

Adrian L Lopresti; Stephen J Smith; Sinan Ali; Alexandra Metse; John Kalns; Peter D Drummond

doi:10.1016/j.jff.2021.104671

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Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study

Journal article

Open access

Peer reviewed

Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study

Adrian L Lopresti, Stephen J Smith, Sinan Ali, Alexandra Metse, John Kalns and Peter D Drummond

Journal of Functional Foods, Vol.85, pp.1-12

2021

DOI: https://doi.org/10.1016/j.jff.2021.104671

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Abstract

Health, Clinical and Counselling Psychology

Nutrition and Dietetics not elsewhere classified

Sleep

Lifestyle interventions

Functional food

Bacopa monnieri

Stress

Cortisol

Herbal

Clinical trial

In this 28-day, randomised, double-blind, placebo-controlled trial, 100 adults with self-reported poor sleep received either a placebo or a standardised Bacopa monnieri extract (150 mg twice daily). Outcome measures included the Bergen Insomnia Scale (primary outcome measure), Functional Outcomes of Sleep Questionnaire, Pittsburgh Sleep Diary, Short Form-36 Health Survey, and the Depression, Anxiety, and Stress Scale. Changes in salivary concentrations of cortisol, dehydroepiandrosterone sulfate, immunoglobulin A (sIgA), α-amylase (sAA), C-reactive protein, melatonin, and the fatigue biomarker index were also assessed. Based on the Bergen Insomnia Scale, Bacopa monnieri did not improve sleep patterns more than the placebo; however, it was associated with greater improvements in emotional wellbeing, general health, and pain-related symptoms. Bacopa monnieri was also associated with greater reductions in sIgA and sAA compared to the placebo. Future clinical trials using varying doses, treatment periods, and objective outcome measures will be important to validate these findings.

Details

Title: Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study
Authors: Adrian L Lopresti (Author) - Murdoch University
Stephen J Smith (Author) - Murdoch University
Sinan Ali (Author) - Salpath Functional Pathology
Alexandra Metse (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
John Kalns (Author) - Hyperion Biotechnology
Peter D Drummond (Author) - Murdoch University
Publication details: Journal of Functional Foods, Vol.85, pp.1-12
Publisher: Elsevier BV
Date published: 2021
DOI: 10.1016/j.jff.2021.104671
ISSN: 2214-9414; 1756-4646
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99558108502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Food Science & Technology; Nutrition & Dietetics

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