Journal article
Effects of Woodsmoke Exposure on Airway Inflammation in Rural Guatemalan Women
PLoS One, Vol.9(3), e88455
2014
Abstract
Background: More than two-fifths of the world's population uses solid fuels, mostly biomass, for cooking. The resulting biomass smoke exposure is a major cause of chronic obstructive pulmonary disease (COPD) among women in developing countries. Objective: To assess whether lower woodsmoke exposure from use of a stove with a chimney, compared to open fires, is associated with lower markers of airway inflammation in young women. Design: We carried out a cross-sectional analysis on a sub-cohort of participants enrolled in a randomized controlled trial in rural Guatemala, RESPIRE. Participants: We recruited 45 indigenous women at the end of the 18-month trial; 19 women who had been using the chimney stove for 18-24 months and 26 women still using open fires. Measurements: We obtained spirometry and induced sputum for cell counts, gene expression of IL-8, TNF-a, MMP-9 and 12, and protein concentrations of IL-8, myeloperoxidase and fibronectin. Exhaled carbon monoxide (CO) and 48-hr personal CO tubes were measured to assess smoke exposure. Results: MMP-9 gene expression was significantly lower in women using chimney stoves. Higher exhaled CO concentrations were significantly associated with higher gene expression of IL-8, TNF-a, and MMP-9. Higher 48-hr personal CO concentrations were associated with higher gene expression of IL-8, TNF- a, MMP-9 and MMP-12; reaching statistical significance for MMP-9 and MMP-12. Conclusions: Compared to using an open wood fire for cooking, use of a chimney stove was associated with lower gene expression of MMP-9, a potential mediator of airway remodeling. Among all participants, indoor biomass smoke exposure was associated with higher gene expression of multiple mediators of airway inflammation and remodeling; these mechanisms may explain some of the observed association between prolonged biomass smoke exposure and COPD.
Details
- Title
- Effects of Woodsmoke Exposure on Airway Inflammation in Rural Guatemalan Women
- Authors
- Michael J Guarnieri (Author) - University of California, United StatesJanet V Diaz (Author) - University of California, United StatesChandreyi Basu (Author) - University of California, United StatesAnaite Diaz (Author) - University del Valle, GuatemalaDaniel Pope (Author) - University of Liverpool, United KingdomKirk R Smith (Author) - University of California, United StatesTone Smith-Sivertsen (Author) - Uni Research, NorwayNigel Bruce (Author) - University of Liverpool, United KingdomColin Solomon (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringJohn McCracken (Author) - University del Valle, GuatemalaJohn R Balmes (Author) - University of California, United States
- Publication details
- PLoS One, Vol.9(3), e88455; 9
- Publisher
- Public Library of Science
- Date published
- 2014
- DOI
- 10.1371/journal.pone.0088455
- ISSN
- 1932-6203
- Copyright note
- Copyright © 2014 Guarnieri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Organisation Unit
- Centre for Human Factors and Systems Science; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449022702621
- Output Type
- Journal article
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- Domestic collaboration
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- Respiratory System
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