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Published VersionCC BY V4.0, Open Access
Journal article
Effects of Propranolol, a beta-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice
Frontiers in Behavioral Neuroscience, Vol.10, pp.1-14
2016
PMID: 27014009
Abstract
Memory reconsolidation impairment using the beta-noradrenergic receptor blocker propranolol is a promising novel treatment avenue for patients suffering from pathogenic memories, such as post traumatic stress disorder (PTSD). However, in order to better inform targeted treatment development, the effects of this compound on memory need to be better characterized via translational research. We examined the effects of systemic propranolol administration in mice undergoing a wide range of behavioral tests to determine more specifically which aspects of the memory consolidation and reconsolidation are impaired by propranolol. We found that propranolol (10 mg/kg) affected memory consolidation in non-aversive tasks (object recognition and object location) but not in moderately (Morris water maze (MWM) to highly (passive avoidance, conditioned taste aversion) aversive tasks. Further, propranolol impaired memory reconsolidation in the most and in the least aversive tasks, but not in the moderately aversive task, suggesting its amnesic effect was not related to task aversion. Moreover, in aquatic object recognition and location tasks in which animals were forced to behave (contrary to the classic versions of the tasks); propranolol did not impair memory reconsolidation. Taken together our results suggest that the memory impairment observed after propranolol administration may result from a modification of the emotional valence of the memory rather than a disruption of the contextual component of the memory trace. This is relevant to the use of propranolol to block memory reconsolidation in individuals with PTSD, as such a treatment would not erase the traumatic memory but only reduce the emotional valence associated with this event.
Details
- Title
- Effects of Propranolol, a beta-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice
- Authors
- Helene Villain - Centre de Recherches sur la Cognition AnimaleAicha Benkahoul - Centre de Recherches sur la Cognition AnimaleAnne Drougard - Centre de Recherches sur la Cognition AnimaleMarie Lafragette - Centre de Recherches sur la Cognition AnimaleElodie Muzotte - Centre de Recherches sur la Cognition AnimaleStephane Pech - Centre de Recherches sur la Cognition AnimaleEric Bui - Massachusetts General HospitalAlain Brunet - Douglas Mental Health University InstitutePhilippe Birmes - Université Fédérale de Toulouse Midi-PyrénéesPascal Roullet (Corresponding Author) - Université Toulouse III - Paul Sabatier
- Publication details
- Frontiers in Behavioral Neuroscience, Vol.10, pp.1-14
- Publisher
- Frontiers Research Foundation
- Date published
- 2016
- DOI
- 10.3389/fnbeh.2016.00049
- ISSN
- 1662-5153
- PMID
- 27014009
- Copyright note
- Copyright © 2016 Villain, Benkahoul, Drougard, Lafragette, Muzotte, Pech, Bui, Brunet, BirmesandRoullet.Thisisanopen-accessarticle distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Grant note
- This study was supported by Center National de la Recherche Scientifique (CNRS) and by the University Paul Sabatier Toulouse III. EB research effort was supported by the Highland Street Foundation, and the Red Sox Foundation and Massachusetts General Hospital Home Base Program.
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 991105839502621
- Output Type
- Journal article
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