Journal article
Effects of Multiday Exposure to Ozone on Airway Inflammation as Determined Using Sputum Induction
Environmental Health Perspectives, Vol.114(2), pp.209-212
2006
Abstract
Single short-term exposures to ozone are known to cause acute changes in pulmonary function and neutrophilic airway inflammation. The respiratory health effects of repeated exposures are not as well studied. Pulmonary function decrements are known to attenuate, but it is less clear how injury and inflammation are affected. Using sputum induction (SI) to sample respiratory tract lining fluid after single- and multiday exposures, we designed a study to test the hypothesis that neutrophils would increase after multiday exposure compared with single-day exposure. In a randomized, crossover design, 15 normal healthy subjects were exposed to O3 (0.2 ppm) under two conditions: for 4 hr for 1 day (1D) and for 4 hr for 4 consecutive days (4D). Pulmonary function testing was performed immediately before and after each 4-hr exposure. The SI was performed 18 hr after the end of the 1D and 4D conditions. The symptom and pulmonary function data followed a pattern seen in other multiday O3 exposure studies, with the greatest changes occurring on the second day. In contrast to previous studies using bronchoalveolar lavage, however, there was a significant increase in the percentage of neutrophils and a significant decrease in the percentage of macrophages after the 4D condition compared with the 1D condition. Given that SI likely samples proximal airways better than distal lung, these results add to the body of evidence that differential airway compartmental responses to O3 occur in humans and other species.
Details
- Title
- Effects of Multiday Exposure to Ozone on Airway Inflammation as Determined Using Sputum Induction
- Authors
- J Ratto (Author) - University of California San Francisco, United StatesH Wong (Author) - University of California San Francisco, United StatesJ Liu (Author) - University of California San Francisco, United StatesJ Fahy (Author) - University of California San Francisco, United StatesH Boushey (Author) - University of California San Francisco, United StatesColin Solomon (Author) - University of California San Francisco, United StatesJ Balmes (Author) - University of California San Francisco, United States
- Publication details
- Environmental Health Perspectives, Vol.114(2), pp.209-212
- Publisher
- National Institute of Environmental Health Sciences, U.S. Department of Health and Human Services
- Date published
- 2006
- DOI
- 10.1289/ehp.8341
- ISSN
- 0091-6765
- Copyright note
- Copyright © 2006. Reproduced with permission from Environmental Health Perspectives. The definitive version is available from http://ehp03.niehs.nih.gov/.
- Organisation Unit
- Centre for Human Factors and Systems Science; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449544002621
- Output Type
- Journal article
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