Journal article
Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine
Neuropharmacology, Vol.47(7), pp.973-984
2004
Abstract
Exposure to environmental cues is considered a major cause of relapse in detoxified addicts. Recent findings showed an involvement of glutamate in cue-induced relapse and suggest that subtype 5 of metabotropic glutamate receptors (mGluR5) is involved in conditioned drug-reward. The present study applied the conditioned place preference (CPP) paradigm to examine the involvement of mGluR5 in cocaine- and morphine-induced behaviours. Results of previous mice-studies were extended into rats by using the selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP). As a result, the evaluated behavioural parameters were dose-relatedly affected by MPEP. Low-dosed MPEP (10 mg/kg, i.p.) did not affect spontaneous locomotion, reduced cocaine-induced hyperlocomotion and produced sensitized locomotion, while showing no effect on sensitized locomotion induced by repeated cocaine or morphine. Low-dosed MPEP did not genuinely block development of cocaine- and morphine-CPP, but rendered CPP expression state-dependent. The medium MPEP-dose (30 mg/kg) was most effective in reducing spontaneous locomotion. The high MPEP-dose (50 mg/kg) was most effective in reducing both body-weight and morphine-CPP expression. Cocaine-CPP expression was not affected by any MPEP-dose. In conclusion, mGluR5 are involved in modulation of spontaneous and cocaine-induced locomotion, in state-dependent learning and in expression of morphine-CPP. Thus, MPEP may be beneficial for relapse prevention in morphine-addicts.
Details
- Title
- Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine
- Authors
- Volker Herzig (Author) - University of Tubingen, GermanyW J Schmidt (Author) - University of Tubingen, Germany
- Publication details
- Neuropharmacology, Vol.47(7), pp.973-984
- Publisher
- Elsevier Ltd.
- Date published
- 2004
- DOI
- 10.1016/j.neuropharm.2004.07.037
- ISSN
- 0028-3908
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450976602621
- Output Type
- Journal article
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- Neurosciences
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