Effects of Intervertebral Disc Infection on the Developing Ovine Spine

Rebecca M Walters; S H E Smith; M J Hutchinson; A M Dolan; R D Fraser; R J Moore

doi:10.1097/01.brs.0000164102.31726.0a

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Effects of Intervertebral Disc Infection on the Developing Ovine Spine

Journal article

Peer reviewed

Effects of Intervertebral Disc Infection on the Developing Ovine Spine

Rebecca M Walters, S H E Smith, M J Hutchinson, A M Dolan, R D Fraser and R J Moore

Spine, Vol.30(11), pp.1252-1257

2005

DOI: https://doi.org/10.1097/01.brs.0000164102.31726.0a

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Abstract

Biomedical Engineering

Clinical Sciences

discitis

lumbar spine

infection

intervertebral disc

discography

sheep

long-term effects

Study Design. A prospective in vivo animal study. Objectives. To determine whether infection in the juvenile spine influences spinal development. Summary of Background Data. Discitis is thought to occur in children when blood-borne infection penetrates the highly vascular immature disc. The condition generally resolves without apparent complication, but little is known about the long-term effects on the growing spine. Methods. Twenty-nine 6-week-old lambs underwent discography at multiple lumbar levels using radiographic contrast deliberately inoculated with Staphylococcus epidermidis. No antibiotics were given. Plain radiographs were taken at intervals up to 52 weeks after inoculation for morphometric analysis of the vertebral bodies and discs, and the lumbar spines were prepared for histology. Results. Sixteen of 44 inoculated discs showed radiological evidence of discitis between 2 and 6 weeks after inoculation. Disc height and disc area were significantly reduced from 2 weeks, and did not recover during the study period. Vertebral body dimensions and overall lumbar spine length were not significantly affected. Conclusion. Infection of juvenile ovine discs impedes disc development but has no significant effect on vertebral body growth.

Details

Title: Effects of Intervertebral Disc Infection on the Developing Ovine Spine
Authors: Rebecca M Walters (Author) - University of Adelaide
S H E Smith (Author) - Adelaide Centre for Spinal Research
M J Hutchinson (Author) - Royal Adelaide Hospital
A M Dolan (Author) - Royal Adelaide Hospital
R D Fraser (Author) - Adelaide Centre for Spinal Research
R J Moore (Author) - University of Adelaide
Publication details: Spine, Vol.30(11), pp.1252-1257
Publisher: Lippincott Williams & Wilkins
Date published: 2005
DOI: 10.1097/01.brs.0000164102.31726.0a
ISSN: 0362-2436
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450490902621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Orthopedics

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