Journal article
Effect of vitamin D supplementation on antibiotic use: A randomized controlled trial
American Journal of Clinical Nutrition, Vol.99(1), pp.156-161
2014
Abstract
Background: Observational data suggested that supplementation with vitamin D could reduce risk of infection, but trial data are inconsistent. Objective: We aimed to examine the effect of oral vitamin D supplementation on antibiotic use. Design: We conducted a post hoc analysis of data from pilot D-Health, which is a randomized trial carried out in a general community setting between October 2010 and February 2012. A total of 644 Australian residents aged 60-84 y were randomly assigned to receive monthly doses of a placebo (n = 214) or 30,000 (n = 215) or 60,000 (n = 215) IU oral cholecalciferol for ≤12 mo. Antibiotics prescribed during the intervention period were ascertained by linkage with pharmacy records through the national health insurance scheme (Medicare Australia). Results: People who were randomly assigned 60,000 IU cholecalciferol had nonsignificant 28% lower risk of having antibiotics prescribed at least once than did people in the placebo group (RR: 0.72; 95% CI: 0.48, 1.07). In analyses stratified by age, in subjects aged ≥70 y, there was a significant reduction in antibiotic use in the high-dose vitamin D compared with placebo groups (RR: 0.53; 95% CI: 0.32, 0.90), whereas there was no effect in participants aged <70 y (RR: 1.07; 95% CI: 0.58, 1.97) (P-interaction = 0.1). Conclusion: Although this study was a post hoc analysis and statistically nonsignificant, this trial lends some support to the hypothesis that supplementation with 60,000 IU vitamin D/mo is associated with lower risk of infection, particularly in older adults. The trial was registered at the Australian New Zealand Clinical Trials Registry (anzctr.org.au) as ACTRN12609001063202. © 2014 American Society for Nutrition.
Details
- Title
- Effect of vitamin D supplementation on antibiotic use: A randomized controlled trial
- Authors
- B Tran (Author) - Queensland Institute of Medical ResearchB K Armstrong (Author) - Sydney School of Public HealthP R Ebeling (Author) - University of MelbourneD R English (Author) - University of MelbourneMichael G Kimlin (Author) - Queensland University of TechnologyJ C Van Der Pols (Author) - Queensland University of TechnologyA Venn (Author) - University of QueenslandV Gebski (Author) - Sydney Medical SchoolD C Whiteman (Author) - Queensland Institute of Medical ResearchP M Webb (Author) - Queensland Institute of Medical ResearchR E Neale (Author) - Queensland University of Technology
- Publication details
- American Journal of Clinical Nutrition, Vol.99(1), pp.156-161
- Publisher
- American Society for Nutrition
- Date published
- 2014
- DOI
- 10.3945/ajcn.113.063271
- ISSN
- 0002-9165
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99449947002621
- Output Type
- Journal article
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