Logo image
Back
Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease
Journal article   Peer reviewed

Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease

G A Barker, S Green, Christopher D Askew, A A Green and P J Walker
Medicine and Science in Sports and Exercise, Vol.33(9), pp.1415-1422
2001
DOI: https://doi.org/10.1097/00005768-200109000-00001
url
https://doi.org/10.1097/00005768-200109000-00001View
Published Version

Abstract

Human Movement and Sports Science Biomedical Engineering peripheral arterial disease exercise performance
Supplementation with propionyl-L-carnitine (PLC) may be of use in improving the exercise capacity of people with peripheral arterial disease. After a 2-wk exercise familiarization phase, seven subjects displaying intermittent claudication were studied over a 12-wk period consisting of three 4-wk phases, baseline (B), supplementation (S), and placebo (P). PLC was supplemented at 2 g[middle dot]d-1, and subjects were blinded to the order of supplementation. Unilateral calf strength and endurance were assessed weekly. Walking performance was assessed at the end of each phase using an incremental protocol, during which respiratory gases were collected. Although there was not a significant increase in maximal walking time (~14%) in the whole group, walking time improved to a greater extent than the individual baseline coefficient of variation in four of the seven subjects. The changes in walking performance were correlated with changes in the respiratory exchange ratio both at steady state (r = 0.59) and maximal exercise (r = 0.79). Muscle strength increased significantly from 695 +/- 198 N to 812 +/- 249 N by the end of S. Changes in calf strength from B to S were modestly related to changes in walking performance (r = 0.56). No improvements in calf endurance were detected throughout the study. These preliminary data suggest that, in addition to walking performance, muscle strength can be increased in PAD patients after 4 wk of supplementation with propionyl-L-carnitine.

Details

Metrics

5 File views/ downloads
716 Record Views
25 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
International collaboration
Web Of Science research areas
Sport Sciences

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Logo image