Journal article
Effect of progesterone and its 5 alpha and 5 beta metabolites on symptoms of premenstrual syndrome according to route of administration
Journal of Psychosomatic Obstetrics and Gynaecology, Vol.17(1), pp.29-38
1996
Abstract
Orally administered progesterone may have advantages over other routes of administration in the treatment of premenstrual syndrome (PMS) because of substantially higher levels of the anxiolytic metabolites 5? and 5? pregnanolone. The only previous placebo-controlled trial which used oral progesterone reported beneficial effects in the treatment of PMS. The present study, a double-blind cross-over trial, compared the administration of 300 mg daily oral progesterone with 200 mg daily vaginal progesterone and matched placebos for 10 days premenstrually. Although there was a significant treatment effect on symptoms, no difference between active treatments and placebo was found. The trial was terminated with 25 women completing treatment as it was evident that no clinically significant effect of either form of progesterone war likely to be detected even with twice the sample size. Serum levels of progesterone and metabolites showed that oral administration resulted in supraphysiological levels of 5? and 5? metabolites and there was a negative correlation between 5? pregnanolone levels and anxiety. However, this did not translate to overall reduction in premenstrual distress or anxiety beyond that achieved by placebo, as measured by validated questionnaires.
Details
- Title
- Effect of progesterone and its 5 alpha and 5 beta metabolites on symptoms of premenstrual syndrome according to route of administration
- Authors
- W Vanselow (Author) - University of MelbourneL Dennerstein (Author) - University of MelbourneKen Greenwood (Author) - University of MelbourneB De Lignieres (Author)
- Publication details
- Journal of Psychosomatic Obstetrics and Gynaecology, Vol.17(1), pp.29-38
- Publisher
- Taylor & Francis Ltd.
- Date published
- 1996
- DOI
- 10.3109/01674829609025661
- ISSN
- 0167-482X
- Organisation Unit
- School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99451178602621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Obstetrics & Gynecology
- Psychiatry
- Psychology, Clinical
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Source: InCites