Journal article
Effect of alteration in pump speed on pump output and left ventricular filling with continuous-flow left ventricular assist device
ASAIO Journal , Vol.57(6), pp.495-500
2011
PMID: 21989420
Abstract
Third-generation continuous-flow left ventricular assist devices (LVAD) provide reduced pulsatility flow. We examined the safe working range for LVAD pump speed and the effect on pump output and cardiac function in 13 stable outpatients with VentrAssist-LVAD (Ventracor Ltd, Australia). Pump speed was decreased from a baseline mean of 2,073 ± 86 revolutions per minute (RPM, with corresponding mean flow of 5.59 ± 1.18 L/min, mean ± standard deviation) to an average low-speed of 1,835 ± 55 RPM (corresponding flow 4.68 ± 0.99 L/min) and up to high-speed of 2,315 ± 66 RPM (corresponding flow 6.30 ± 1.29 L/min). There was a strong linear relationship between alteration in speed and flow rates (r(2) = 0.89, p < 0.00001) but marked interpatient variation. Downward titration to preset minimum 1,800 RPM was achieved in 9/13 (69%) and upward titration to the preset maximum 2,400 RPM was achieved in 4/13 (31%). Upward titration was stopped due to ventricular suction or nonsustained ventricular tachycardia (VT) in 4/13 (31%). Ventricular suction or VT (in 4/13) tended to be more common in patients with poor right ventricular (RV) function (p = 0.07). In summary, pump flow is stable within a relatively small speed range and should not be altered without close monitoring due to variation in response between patients, particularly with concomitant RV impairment.
Details
- Title
- Effect of alteration in pump speed on pump output and left ventricular filling with continuous-flow left ventricular assist device
- Authors
- Christopher S Hayward (Author) - St Vincent's Hospital SydneyRobert Salamonsen (Author) - Alfred HospitalAnne M Keogh (Author) - St Vincent's Hospital SydneyJohn Woodard (Author) - World Heart CorporationPeter Ayre (Author) - National Information and Communications Technology Centre of ExcellenceRoslyn Prichard (Author) - St Vincent's Hospital SydneyRobyn Walker (Author) - St Vincent's Hospital SydneyEugene Kotlyar (Author) - St Vincent's Hospital SydneyPeter S Macdonald (Author) - St Vincent's Hospital SydneyPaul Jansz (Author) - St Vincent's Hospital SydneyPhillip Spratt (Author) - St Vincent's Hospital Sydney
- Publication details
- ASAIO Journal , Vol.57(6), pp.495-500
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/MAT.0b013e318233b112
- ISSN
- 1538-943X
- PMID
- 21989420
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Nursing, Midwifery and Paramedicine - Legacy; School of Health - Nursing
- Language
- English
- Record Identifier
- 99512808602621
- Output Type
- Journal article
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- Domestic collaboration
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- Engineering, Biomedical
- Transplantation
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