Journal article
Effect of age, gender and mannose-binding lectin (MBL) status on the inflammatory profile in peripheral blood plasma of Australian blood donors
Human Immunology, Vol.75(9), pp.973-979
2014
PMID: 25167768
Abstract
Transfusion of blood components has been associated with poor patient outcomes and, an overall increase in morbidity and mortality. Differences in the blood components arising from donor health, age and immune status may impact on outcomes of transfusion and transfusion-related immune modulation in recipients. The aim of this study was to investigate differences in inflammatory profile in donors and association with parameters including age, gender and deficiency status of pattern recognition molecule mannose-binding lectin (MBL). MBL level was determined by ELISA. Serum levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12, tumour necrosis factor (TNF)-α, macrophage inflammatory protein (MIP)-1α, monocyte chemoattractant protein (MCP)-1, interferon (IFN)-α, and IFN-γ were examined by cytometric bead array (CBA). C-reactive protein (CRP) and rheumatoid factor (RF) were examined by immunoturbidimetry. This study demonstrated age was a parameter associated with the immune profile of blood donors, with significant increases in MCP-1 (. p<. 0.05) and RF (. p<. 0.05) and decreases in IL-1α evident in the older donors (61-76. years). Significant gender-associated differences in MCP-1, IL-12 and CRP plasma levels in the blood donor cohort were also reported. There was no significant difference in the level of any inflammatory markers studied according to MBL status. This study demonstrated that age and gender are associated with inflammatory profile in donors. These differences may be a factor impacting on outcomes of transfusion.
Details
- Title
- Effect of age, gender and mannose-binding lectin (MBL) status on the inflammatory profile in peripheral blood plasma of Australian blood donors
- Authors
- Katrina Kildey (Author) - Queensland University of TechnologyKelly Rooks (Author) - Australian Red Cross Blood ServiceSteven Weier (Author) - Queensland University of TechnologyRobert L Flower (Author) - Queensland University of TechnologyMelinda M Dean (Author) - Queensland University of Technology
- Publication details
- Human Immunology, Vol.75(9), pp.973-979
- Publisher
- Elsevier Inc.
- Date published
- 2014
- DOI
- 10.1016/j.humimm.2014.08.200
- ISSN
- 0198-8859; 1879-1166; 0198-8859
- PMID
- 25167768
- Organisation Unit
- School of Health - Biomedicine; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99513783702621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Immunology
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Source: InCites