Effect of a High Linoleic Acid Diet on Pregnant Women and Their Offspring

Deepti Nayyar; Joanne M. Said; Helen McCarthy; Deanne H. Hryciw; Lannie O'Keefe; Andrew J. McAinch

doi:10.3390/nu16173019

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Effect of a High Linoleic Acid Diet on Pregnant Women and Their Offspring

Journal article

Open access

Peer reviewed

Effect of a High Linoleic Acid Diet on Pregnant Women and Their Offspring

Deepti Nayyar, Joanne M. Said, Helen McCarthy, Deanne H. Hryciw, Lannie O'Keefe and Andrew J. McAinch

Nutrients, Vol.16(17), pp.1-16

2024

DOI: https://doi.org/10.3390/nu16173019

PMID: 39275331

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Abstract

nutrition

linoleic acid

alpha linoleic acid

birth weight

inflammatory markers

placenta

Nutritional intake during pregnancy can affect gestational length, fetal development, and impact postnatal growth and health in offspring. Perturbations in maternal nutrition with either an excess or deficiency in nutrients during pregnancy may have harmful effects on the offspring's development and increase the risk of developing chronic diseases later in life. In pregnancy, nutrients transfer from the mother to the fetus via the placenta. Essential fatty acids, linoleic acid (LA) and alpha linoleic acid (ALA), can only be obtained in the diet. In Western countries, the ratio of LA and ALA in the diet has increased dramatically in recent decades. Some animal and human studies have found a correlation between maternal intake of LA and birth weight; however, the association varies. In contrast, some human studies have demonstrated inconclusive findings regarding the correlation between cord blood levels of LA and birth outcomes. In addition, high dietary LA intake in animal studies in pregnancy increased the production of inflammatory markers such as prostaglandins, leukotrienes, cytokines, and tumour necrosis factor-alpha. This review aims to highlight the effect of high dietary LA intake during pregnancy on birth outcomes, obesity, maternal inflammatory markers, and the transfer of fatty acids across the placenta.

Details

Title: Effect of a High Linoleic Acid Diet on Pregnant Women and Their Offspring
Authors: Deepti Nayyar - Victoria University
Joanne M. Said - Sunshine Hospital
Helen McCarthy - Victoria University
Deanne H. Hryciw - Griffith University
Lannie O'Keefe - Victoria University
Andrew J. McAinch (Corresponding Author) - Australian Institute for Musculoskeletal Science
Publication details: Nutrients, Vol.16(17), pp.1-16
Publisher: MDPI AG
Date published: 2024
DOI: 10.3390/nu16173019
ISSN: 2072-6643
PMID: 39275331
Copyright note: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Health - Biomedicine
Language: English
Record Identifier: 991186520802621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Nutrition & Dietetics

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