Journal article
Effect of a 3-Year Lifestyle Intervention in Patients with Chronic Kidney Disease: A Randomized Clinical Trial
Journal of the American Society of Nephrology, Vol.33(2), pp.431-441
2022
PMCID: PMC8819984
PMID: 34893535
Abstract
Supervised lifestyle interventions have the potential to significantly improve physical activity and fitness in patients with CKD. To assess the efficacy of a lifestyle intervention in patients with CKD to improve cardiorespiratory fitness and exercise capacity over 36 months, we conducted a randomized clinical trial, enrolling 160 patients with stage 3-4 CKD, with 81 randomized to usual care and 79 to a 3-year lifestyle intervention. The lifestyle intervention comprised care from a multidisciplinary team, including a nephrologist, nurse practitioner, exercise physiologist, dietitian, diabetes educator, psychologist, and social worker. The exercise training component consisted of an 8-week individualized and supervised gym-based exercise intervention followed by 34 months of a predominantly home-based program. Self-reported physical activity (metabolic equivalent of tasks [METs] minutes per week), cardiorespiratory fitness (peak O consumption [VO]), exercise capacity (maximum METs and 6-minute walk distance) and neuromuscular fitness (grip strength and get-up-and-go test time) were evaluated at 12, 24, and 36 months.The intervention increased the percentage of patients meeting physical activity guideline targets of 500 MET min/wk from 29% at baseline to 63% at 3 years. At 12 months, both VO and METs increased significantly in the lifestyle intervention group by 9.7% and 30%, respectively, without change in the usual care group. Thereafter, VO declined to near baseline levels, whereas METs remained elevated in the lifestyle intervention group at 24 and 36 months. After 3 years, the intervention had increased the 6-minute walk distance and blunted declines in the get-up-and-go test time. A 3-year lifestyle intervention doubled the percentage of CKD patients meeting physical activity guidelines, improved exercise capacity, and ameliorated losses in neuromuscular and cardiorespiratory fitness.
Details
- Title
- Effect of a 3-Year Lifestyle Intervention in Patients with Chronic Kidney Disease: A Randomized Clinical Trial
- Authors
- Kassia S Beetham (Author) - The University of QueenslandRathika Krishnasamy (Author) - Sunshine Coast University Hospital (Australia)Tony Stanton (Author) - University of the Sunshine CoastJulian W Sacre (Author) - Baker Heart and Diabetes InstituteBettina Douglas (Author) - The University of QueenslandNicole M Isbel (Author) - Princess Alexandra HospitalJeff S Coombes (Author) - The University of QueenslandErin J Howden (Corresponding Author) - Baker Heart and Diabetes Institute
- Publication details
- Journal of the American Society of Nephrology, Vol.33(2), pp.431-441
- Publisher
- American Society of Nephrology
- Date published
- 2022
- DOI
- 10.1681/ASN.2021050668
- ISSN
- 1533-3450
- PMID
- 34893535; PMC8819984
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99605106502621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Urology & Nephrology
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