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Effect of Selenium and Iodine on Oxidative Stress in the First Trimester Human Placenta Explants1.15 MB
Published VersionCC BY V4.0, Open Access
Journal article
Effect of Selenium and Iodine on Oxidative Stress in the First Trimester Human Placenta Explants
Nutrients, Vol.13(3), pp.1-14
2021
PMID: 33671070
Abstract
Imbalanced maternal micronutrient status, poor placentation, and oxidative stress are associated with greater risk of pregnancy complications, which impact mother and offspring health. As selenium, iodine, and copper are essential micronutrients with key roles in antioxidant systems, this study investigated their potential protective effects on placenta against oxidative stress. First trimester human placenta explants were treated with different concentrations of selenium (sodium selenite), iodine (potassium iodide), their combination or copper (copper (II) sulfate). The concentrations represented deficient, physiological, or super physiological levels. Oxidative stress was induced by menadione or antimycin. Placenta explants were collected, fixed, processed, and embedded for laser ablation inductively coupled plasma-mass spectrometry (LA ICP-MS) element imaging or immunohistochemical labelling. LA ICP-MS showed that placenta could uptake selenium and copper from the media. Sodium selenite and potassium iodide reduced DNA damage and apoptosis (p < 0.05). Following oxidative stress induction, a higher concentration of sodium selenite (1.6 mu M) was needed to reduce DNA damage and apoptosis while both concentrations of potassium iodide (0.5 and 1 mu M) were protective (p < 0.05). A high concentration of copper (40 mu M) increased apoptosis and DNA damage but this effect was no longer significant after induction of oxidative stress. Micronutrients supplementation can increase their content within the placenta and an optimal maternal micronutrient level is essential for placenta health.
Details
- Title
- Effect of Selenium and Iodine on Oxidative Stress in the First Trimester Human Placenta Explants
- Authors
- Nahal Habibi (Author) - The University of AdelaideAgatha Labrinidis (Author) - The University of AdelaideShalem Yiner-Lee Leemaqz (Author) - Flinders UniversityTanja Jankovic-Karasoulos (Author) - Flinders UniversityDylan McCullough (Author) - Flinders UniversityJessica A. Grieger (Author) - The University of AdelaideSarah Gilbert (Author) - The University of AdelaideCarmela Ricciardelli (Author) - The University of AdelaideShao Jia Zhou (Author) - The University of AdelaideAnthony Perkins (Author) - Griffith UniversityClaire T. Roberts (Author) - Flinders UniversityTina Bianco-Miotto (Corresponding Author) - The University of Adelaide
- Publication details
- Nutrients, Vol.13(3), pp.1-14
- Publisher
- MDPI AG
- Date published
- 2021
- DOI
- 10.3390/nu13030800
- ISSN
- 2072-6643
- PMID
- 33671070
- Copyright note
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Grant note
- Flinders University Matthew Flinders Fellowship GNT1161079 / National Health and Medical Research Council (NHMRC); National Health and Medical Research Council (NHMRC) of Australia GNT1174971 / NHMRC Investigator Grant; National Health and Medical Research Council (NHMRC) of Australia
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685293702621
- Output Type
- Journal article
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