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Published VersionCC BY V4.0, Open Access
Journal article
Effect of Pregnancy for Females Born Small on Later Life Metabolic Disease Risk
PLoS One, Vol.7(9), pp.1-8
2012
PMCID: PMC3441641
PMID: 23028837
Abstract
There is a strong inverse relationship between a females own birth weight and her subsequent risk for gestational diabetes with increased risk of developing diabetes later in life. We have shown that growth restricted females develop loss of glucose tolerance during late pregnancy with normal pancreatic function. The aim of this study was to determine whether growth restricted females develop long-term impairment of metabolic control after an adverse pregnancy adaptation. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham surgery (Control) in late pregnancy (E18) in F0 female rats. F1 Control and Restricted female offspring were mated with normal males and allowed to deliver (termed Ex-Pregnant). Age-matched Control and Restricted Virgins were also studied and glucose tolerance and insulin secretion were determined. Pancreatic morphology and hepatic glycogen and triacylglycerol content were quantified respectively. Restricted females were born lighter than Control and remained lighter at all time points studied (p<0.05). Glucose tolerance, first phase insulin secretion and liver glycogen and triacylglycerol content were not different across groups, with no changes in beta-cell mass. Second phase insulin secretion was reduced in Restricted Virgins (-34%, p<0.05) compared to Control Virgins, suggestive of enhanced peripheral insulin sensitivity but this was lost after pregnancy. Growth restriction was associated with enhanced basal hepatic insulin sensitivity, which may provide compensatory benefits to prevent adverse metabolic outcomes often associated with being born small. A prior pregnancy was associated with reduced hepatic insulin sensitivity with effects more pronounced in Controls than Restricted. Our data suggests that pregnancy ameliorates the enhanced peripheral insulin sensitivity in growth restricted females and has deleterious effects for hepatic insulin sensitivity, regardless of maternal birth weight.
Details
- Title
- Effect of Pregnancy for Females Born Small on Later Life Metabolic Disease Risk
- Authors
- Melanie Tran (Author) - The University of MelbourneLinda A. Gallo (Author) - The University of MelbourneGlenn D. Wadley (Author) - Deakin UniversityAndrew J. Jefferies (Author) - The University of MelbourneKaren M. Moritz (Author) - The University of QueenslandMary E. Wlodek (Corresponding Author) - The University of Melbourne
- Publication details
- PLoS One, Vol.7(9), pp.1-8
- Publisher
- Public Library of Science
- Date published
- 2012
- DOI
- 10.1371/journal.pone.0045188
- ISSN
- 1932-6203
- PMID
- 23028837; PMC3441641
- Copyright note
- Copyright: © 2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99679193602621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
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Source: InCites