Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease

Eid Abo Hamza; Ahmed A Moustafa; Richard Tindle; Rasu Karki; Shahed Nalla; Mohamed S Hamid; Mohamad El Haj

doi:10.2174/1567205020666230309113749

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Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease

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Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease

Eid Abo Hamza, Ahmed A Moustafa, Richard Tindle, Rasu Karki, Shahed Nalla, Mohamed S Hamid and Mohamad El Haj

Current Alzheimer Research, Vol.19(14), pp.943-953

2022

DOI: https://doi.org/10.2174/1567205020666230309113749

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Abstract

Alzheimer's disease

hippocampus

APOE gene

entorhinal cortex

fusiform gyrus

disease progression

gender differences

Background: The hippocampus, entorhinal cortex, and fusiform gyrus are brain areas that deteriorate during early-stage Alzheimer’s disease (AD). The ApoE4 allele has been identified as a risk factor for AD development, is linked to an increase in the aggregation of amyloid β (Aβ) plaques in the brain, and is responsible for atrophy of the hippocampal area. However, to our knowledge, the rate of deterioration over time in individuals with AD, with or without the ApoE4 allele, has not been investigated. Methods: In this study, we, for the first time, analyze atrophy in these brain structures in AD patients with and without the ApoE4 using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Results: It was found that the rate of decrease in the volume of these brain areas over 12 months was related to the presence of ApoE4. Further, we found that neural atrophy was not different for female and male patients, unlike prior studies, suggesting that the presence of ApoE4 is not linked to the gender difference in AD. Conclusion: Our results confirm and extend previous findings, showing that the ApoE4 allele gradually impacts brain regions impacted by AD.

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Title: Effect of APOE4 Allele and Gender on the Rate of Atrophy in the Hippocampus, Entorhinal Cortex, and Fusiform Gyrus in Alzheimer's Disease
Authors: Eid Abo Hamza (Author) - Tanta University
Ahmed A Moustafa (Corresponding Author) - Bond University
Richard Tindle (Author) - University of the Sunshine Coast, Queensland, School of Health - Psychology
Rasu Karki (Author) - Western Sydney University
Shahed Nalla (Author) - University of Johannesburg
Mohamed S Hamid (Author) - Ain Shams University
Mohamad El Haj (Author) - Laboratoire de Psychologie des Pays de la Loire
Publication details: Current Alzheimer Research, Vol.19(14), pp.943-953
Publisher: Bentham Science Publishers Ltd.
DOI: 10.2174/1567205020666230309113749
ISSN: 1875-5828
Organisation Unit: School of Education and Tertiary Access; School of Health - Psychology; Indigenous and Transcultural Research Centre
Language: English
Record Identifier: 99716033902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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