Journal article
Early adolescent psychological distress and cognition, correlates of resting-state EEG, interregional phase-amplitude coupling
International Journal of Psychophysiology, Vol.183, pp.130-137
2023
PMID: 36436723
Appears in Thompson Institute Research Collection
Abstract
Delineating neurobiological markers of youth mental health is crucial for early identification and treatment. One promising marker is phase-amplitude coupling (PAC), cross-frequency coupling between the phase of slower oscillatory activity and the amplitude of faster oscillatory activity in the brain. Prior research has demonstrated that PAC is associated with both cognition and mental health and can be modulated using neurostimulation. However, to date research investigating PAC has focused primarily on adults, and only within-region theta-gamma coupling in the context of mental health. We investigated associations between interregional resting-state PAC (posterior-anterior cortex), and cognition and psychological distress in N = 77 (Mage = 12.58 years, SD = 0.31; 51 % female) 12-year-olds. Firstly, while left theta-beta PAC showed a moderate positive correlation (r = 0.529, p < .01), right theta-gamma PAC showed a weak positive correlation, with psychological distress (r = 0.283, p < .05). In terms of cognition, moderate correlations were observed between: (i) increased left theta-beta PAC and increased psychomotor speed (r = −0.367, p < .05); (ii) increased left alpha-beta PAC and decreased attention (r = 0.355, p ≤0.01); and (iii) increased left alpha-beta PAC and decreased verbal learning and memory (r = −0.352, p < .01). Whereas weak associations were observed for: (i) increased left alpha-beta PAC and decreased executive functioning scores (r = 0.284, p < .05); and (ii) increased left alpha-gamma PAC and increased attention (r = −0.272, p < .05). The overall findings of this exploratory study are encouraging, although all the correlations were in the weak-to-moderate range and require replication. Further research may confirm interregional resting-state PAC as a biomarker that can help us better understand the link between mental health and cognition in adolescents and improve treatment of cognitive related deficits in mental illness.
Details
- Title
- Early adolescent psychological distress and cognition, correlates of resting-state EEG, interregional phase-amplitude coupling
- Authors
- D D Sacks (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteP E Schwenn (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteT De Regt (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteC Driver (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteL T McLoughlin (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJ Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteD F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- International Journal of Psychophysiology, Vol.183, pp.130-137
- Publisher
- Elsevier BV
- Date published
- 2023
- DOI
- 10.1016/j.ijpsycho.2022.11.012
- ISSN
- 1872-7697
- PMID
- 36436723
- Organisation Unit
- Engage Research Lab; Thompson Institute; School of Health - Psychology
- Language
- English
- Record Identifier
- 99695749102621
- Output Type
- Journal article
Metrics
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Neurosciences
- Physiology
- Psychology
- Psychology, Biological
- Psychology, Experimental
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Source: InCites