ERP indices of working memory updating in AD/HD: Differential aspects of development, subtype, and medication

H A D Keage; C R Clark; Daniel F Hermens; L M Williams; M R Kohn; S Clarke; C Lamb; D Crewther; E Gordon

doi:10.1097/WNP.0b013e318163ccc0

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ERP indices of working memory updating in AD/HD: Differential aspects of development, subtype, and medication

Journal article

Peer reviewed

ERP indices of working memory updating in AD/HD: Differential aspects of development, subtype, and medication

H A D Keage, C R Clark, Daniel F Hermens, L M Williams, M R Kohn, S Clarke, C Lamb, D Crewther and E Gordon

Journal of Clinical Neurophysiology, Vol.25(1), pp.32-41

2008

DOI: https://doi.org/10.1097/WNP.0b013e318163ccc0

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Abstract

working memory

ERP

AD/HD

Subtype

Age

This study investigated whether children and adolescents diagnosed with the predominantly inattentive and combined subtypes of attention deficit/hyperactivity disorder (AD/HD-in and AD/HD-com, respectively) differed on psychophysiological indices of working memory updating off- and on-stimulant medication, as compared with control subjects and each other. ERPs were recorded in AD/HD and control participants during a one-back working memory task. The N100 (discrimination), P150 (selection), N300 (memory retrieval), and P450wm (updating) components after nontarget stimuli, which served to update working memory with target identity, were assessed. Premedication abnormalities were obtained for the N300 component, delayed in the child AD/HD-com group, and attenuated in the adolescent AD/HD-in group and P450wm component for all AD/HD groups, expressed as either delayed latency and/or attenuated amplitude. ERP abnormalities were predominantly ameliorated after stimulant medication. There were no psychophysiological differences between the subtypes. A general feature of the disorder relates to a deficit in the conscious updating of working memory systems with newly relevant information (P450wm), which varies with age and subtype. Children with AD/HD-com and adolescents with AD/HD-in also exhibit abnormalities in the retrieval of relevant prior memories (N300). This study indicates that AD/HD is related to abnormalities in the capacity to modulate the content of working memory stores. Copyright © 2008 American Clinical Neurophysiology Society.

Details

Title: ERP indices of working memory updating in AD/HD: Differential aspects of development, subtype, and medication
Authors: H A D Keage (Author) - Flinders University
C R Clark (Author) - Flinders University
Daniel F Hermens (Author) - University of Sydney
L M Williams (Author) - University of Sydney
M R Kohn (Author) - Westmead Hospital
S Clarke (Author) - Westmead Hospital
C Lamb (Author) - Flinders Medical Centre
D Crewther (Author) - Swinburne University
E Gordon (Author) - University of Sydney
Publication details: Journal of Clinical Neurophysiology, Vol.25(1), pp.32-41
Publisher: Lippincott Williams & Wilkins
Date published: 2008
DOI: 10.1097/WNP.0b013e318163ccc0
ISSN: 0736-0258
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451202602621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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