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ENIGMA MDD_ seven years of global neuroimaging studies of major depression through worldwide data sharing2.75 MB
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Journal article
ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
Translational Psychiatry, Vol.10, pp.1-19
2020
PMID: 32472038
Appears in Thompson Institute Research Collection
Abstract
A key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.
Details
- Title
- ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
- Authors
- Lianne Schmaal (Author) - The University of MelbourneElena Pozzi (Author) - The University of MelbourneTiffany C Ho (Author) - University of California, San FranciscoLaura S van Velzen (Author) - The University of MelbourneIlya M Veer (Author) - Berlin Institute of Health at Charité - Universitätsmedizin BerlinNils Opel (Author) - University of MünsterEus J. W Van Someren (Author) - VU University AmsterdamLaura K. M Han (Author) - Vrije Universiteit BrusselLybomir Aftanas (Author) - Novosibirsk State UniversityAndré Aleman (Author) - University of GroningenBernhard T Baune (Author) - University of MünsterKlaus Berger (Author) - University of MünsterTessa F Blanken (Author) - VU University AmsterdamLiliana Capitão (Author) - University of OxfordBaptiste Couvy-Duchesne (Author) - The University of QueenslandKathryn R Cullen (Author) - University of MinnesotaUdo Dannlowski (Author) - University of MünsterChristopher Davey (Author) - The University of MelbourneTracy Erwin-Grabner (Author) - University of GöttingenJennifer Evans (Author) - National Institute of Mental HealthThomas Frodl (Author) - National Institute of Mental HealthCynthia H. Y Fu (Author) - King's College LondonBeata Godlewska (Author)Ian H Gotlib (Author) - Stanford UniversityRoberto Goya-Maldonado (Author) - University of GöttingenHans J Grabe (Author) - Universität GreifswaldNynke A Groenewold (Author) - University of Cape TownDominik Grotegerd (Author) - University of MünsterOliver Gruber (Author) - University Hospital HeidelbergBoris A Gutman (Author) - Illinois Institute of TechnologyGeoffrey B Hall (Author) - McMaster UniversityBen J Harrison (Author) - The University of MelbourneSean N Hatton (Author) - The University of SydneyMarco Hermesdorf (Author) - University of MünsterIan B Hickie (Author) - The University of SydneyEva Hilland (Author) - University of OsloBenson Irungu (Author) - The University of Texas Health Science Center at HoustonRune Jonassen (Author) - OsloMet – Oslo Metropolitan UniversitySinead Kelly (Author) - Harvard Medical SchoolTilo Kircher (Author) - Philipps University of MarburgBonnie Klimes-Dougan (Author) - University of MinnesotaAxel Krug (Author) - Philipps University of MarburgNils Inge Landrø (Author) - University of OsloJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJeanne Leerssen (Author) - Netherlands Institute for NeuroscienceMeng Li (Author) - Jena University HospitalDavid E. J Linden (Author) - Cardiff UniversityFrank P MacMaster (Author) - University of CalgaryAndrew M McIntosh (Author) - University of EdinburghDavid M. A Mehler (Author) - Cardiff UniversityIgor Nenadić (Author) - Philipps University of MarburgBrenda W. J. H Penninx (Author) - Vrije Universiteit BrusselMaria J Portella (Author) - Centro de Investigación Biomédica en Red de Salud MentalLiesbeth Reneman (Author) - Amsterdam UMC Location University of AmsterdamMiguel E Rentería (Author) - QIMR Berghofer Medical Research InstituteMatthew D Sacchet (Author) - Harvard Medical SchoolPhilipp G Sämann (Author) - Max Planck Institute of PsychiatryAnouk Schrantee (Author) - Amsterdam UMC Location University of AmsterdamKang Sim (Author) - National University of SingaporeJair C Soares (Author) - The University of Texas Health Science Center at HoustonDan J Stein (Author) - University of Cape TownLeonardo Tozzi (Author) - Stanford UniversityNic J. A van Der Wee (Author) - Leiden University Medical CenterMarie-José van Tol (Author) - University Medical Center GroningenRobert Vermeiren (Author) - Leiden University Medical CenterYolanda Vives-Gilabert (Author) - Valencia, SpainHenrik Walter (Author) - Berlin Institute of Health at Charité - Universitätsmedizin BerlinMartin Walter (Author) - Leibniz Institute for NeurobiologyHeather C Whalley (Author) - University of EdinburghKatharina Wittfeld (Author) - Universität GreifswaldSarah Whittle (Author) - The University of MelbourneMargaret J Wright (Author) - The University of QueenslandTony T Yang (Author) - University of California, San FranciscoCarlos Zarate (Author) - National Institute of Mental HealthSophia I Thomopoulos (Author) - University of Southern CaliforniaNeda Jahanshad (Author) - University of Southern CaliforniaPaul M Thompson (Author) - University of Southern CaliforniaDick J Veltman (Author) - Amsterdam UMC - Vrije Universiteit Amsterdam
- Publication details
- Translational Psychiatry, Vol.10, pp.1-19
- Publisher
- Nature Publishing Group
- Date published
- 2020
- DOI
- 10.1038/s41398-020-0842-6
- ISSN
- 2158-3188
- PMID
- 32472038
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Grants
- Grant note
- See article text for complete list of funders.
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 99482307002621
- Output Type
- Journal article
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