Dysregulated sleep-wake cycles in young people are associated with emerging stages of major mental disorders

E M Scott; R Robillard; Daniel F Hermens; S L Naismith; N L Rogers; T K C Ip; D White; A Guastella; B Whitwell; K Leigh Smith; I B Hickie

doi:10.1111/eip.12143

Back

Dysregulated sleep-wake cycles in young people are associated with emerging stages of major mental disorders

Journal article

Peer reviewed

Dysregulated sleep-wake cycles in young people are associated with emerging stages of major mental disorders

E M Scott, R Robillard, Daniel F Hermens, S L Naismith, N L Rogers, T K C Ip, D White, A Guastella, B Whitwell, K Leigh Smith, …

Early Intervention in Psychiatry, Vol.10(1), pp.63-70

2016

DOI: https://doi.org/10.1111/eip.12143

Files and links (1)

url

https://doi.org/10.1111/eip.12143View

Published Version

Abstract

circadian rhythm

illness stage

mental disorders

sleep

youth

Aim: To determine if disturbed sleep-wake cycle patterns in young people with evolving mental disorder are associated with stages of illness. Methods: The sleep-wake cycle was monitored using actigraphy across 4 to 22 days. Participants (21 healthy controls and 154 persons seeking help for mental health problems) were aged between 12 and 30 years. Those persons seeking mental health care were categorized as having mild symptoms (stage 1a), an 'attenuated syndrome' (stage 1b) or an 'established mental disorder' (stage 2+). Results: The proportions of individuals with a delayed weekdays sleep schedule increased progressively across illness stages: 9.5% of controls, 11.1% of stage 1a, 25.6% of stage 1b, and 50.0% of stage 2+ (χ2 (3 d.f.)=18.4, P<0.001). A similar pattern was found for weekends (χ2 (3 d.f.)=7.6, P=0.048). Compared with controls, stage 1b participants had later sleep onset on weekends (P=0.015), and participants at stages 1b and 2+ had later sleep offset on both weekdays and weekends (P<0.020). Compared with controls, all participants with mental disorders had more wake after sleep onset (P<0.029) and those at stages 1a and 2+ had lower sleep efficiency (P<0.040). Older age, medicated status and later weekdays sleep offset were found to be the three strongest correlates of later versus earlier clinical stages. Conclusions: In relation to clinical staging of common mental disorders in young people, the extent of delayed sleep phase is associated with more severe or persistent phases of illness. © 2016 John Wiley &Sons Australia, Ltd.

Details

Title: Dysregulated sleep-wake cycles in young people are associated with emerging stages of major mental disorders
Authors: E M Scott (Author) - University of Sydney
R Robillard (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
N L Rogers (Author) - University of Sydney
T K C Ip (Author) - University of Sydney
D White (Author) - University of Sydney
A Guastella (Author) - University of Sydney
B Whitwell (Author) - University of Sydney
K Leigh Smith (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Publication details: Early Intervention in Psychiatry, Vol.10(1), pp.63-70
Publisher: Wiley-Blackwell Publishing Asia
Date published: 2016
DOI: 10.1111/eip.12143
ISSN: 1751-7885
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450455802621
Output Type: Journal article

Metrics

3911 Record Views

19 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites